Expression of MMP9 and TIMP1 gene in primary liver cancer
LI Mingyi, YAO Jinke, YANG Yongguang. Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong province, 524001, China
Objective To investigate the expression of MMP9 and TIMP1 gene and its role of the invasion and metastasis in primary liver cancer (PLC). Methods MMP9 and TIMP1 mRNA expression in 34 PLCs and 12 normal liver specimens was detected by RT-PCR. Results Compared with the control group, MMP9 mRNA expression increased, but TIMP1 mRNA expression decreased in PLCs, especially in those with metastasis (P0.05). There was a negative correlation between TIMP1 and MMP9 mRNA expression (P0.01). Conclusion MMP9 mRNA up-expression and TIMP1 mRNA down-expression might be related to the invasion and metastasis in PLC.