Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Dermatology》 2004-09
Add to Favorite Get Latest Update

The Study of ERK Pathway Related Protein Expression in Malignant Melanoma and Ordinary Nevi

LIN Tong, SUN Jian-fang, ZENG Xue-si, SANG Hong-gui, LI A-mei, ZHAO Liang. Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing 210042, China  
Objective To investigate the roles of extracellular signal-regulated kinase (ERK)1, ERK2 and Cyclin D1 proteins in malignant melanoma (MM) and ordinary nevus. Methods By SP immunohistochemical method, the expression of ERK1, ERK2 and Cyclin D1 proteins was detected in 30 cases of MM and 13 cases of ordinary nevi. Results The expression of ERK1, ERK2 and Cyclin D1 proteins was higher in MMs than that in ordinary nevi (P 0.01). The expression of ERK1, ERK2 and Cyclin D1 was not correlated with Clark level and Breslow thickness. The expression of ERK1 and ERK2 was correlated with that of Cyclin D1. Conclusions ERK pathway is activated in MM and may result in Cyclin D1 over-expression, while in ordinary nevi, only expression of type A nevus cell is increased.
【CateGory Index】: R739.5;R758.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 LI Miao, CHEN Yu-ping, WANG Gang, LI Chun-ying, YIN He-hui, TIAN Yan-li, GAO Tian-wen~*Department of Dermatology Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;A specific human scFv against malignant melanoma selected from a large human phage antibody library[J];Journal of Cellular and Molecular Immunology;2005-05
2 GAO Ying,LI Chun-ying,MA Cui-ling,YIN He-hui, GAO Tian-wen.Department of Dermatology, Xijing Hospital,Fourth Military Medical University, Xi'an 710032, China;Expression of Double-stranded RNA-dependent Protein Kinase in Malignant Melanoma and Ordinary Nevi[J];Chinese Journal of Dermatology;2005-12
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 SUN Xin (Department of Microbiology & Parasitology,Bengbu Medical College,Anhui 233003 ,China);Proliferation of Toxoplasma gondii tachyzoites and its expression of mitogen activated protein kinases in host cells[J];Journal of Bengbu Medicinae College;2002-04
2 FENG De yun, CHENG Rui xue, ZHENG Hui, et al. (Department of Pathology, Xiangya Hospital, Central South University, Changsha 410078, China);Relationship between the expression of PTEN protein and phosphorylation of MAPK in hepatocellular carcinomas and their surrounding liver tissues[J];Bulletin of Hunan Medical University;2002-02
3 Yang Xiaodi, Chen Xingzhi, Sun Xin, Xia Hui, Fang Qiang, Hu Shoufeng, Xu Shenggui, Wang Yuanyuan. Department of Microbiology & Parasitology, Bengbu Medical College, Anhui Provincial Key Laboratory of Infection & Immunity, Anhui Bengbu, 233030 China.;The influence of mitogen activated protein kinases inhibitor on the Toxoplasma gondii tachyzoites invading to host cells[J];Journal of Tropical Diseases and Parasitology;2006-01
4 WANG Gang, WANG Yan , HUA Bing , LIU Xiao-lin QIAO Yuan-yuan Navy General Hospital, Beijing 100037,P. R China;Construction of a large naive human antibody library[J];Journal of Cellular and Molecular Immunology;2002-01
5 ;转化生长因子β_1在肝纤维化中的作用[J];World Chinese Journal of Digestology;2000-01
6 De-Bing Xiang, Xiao-Hua Wu, Zeng-Peng Li, Department of Pathology, Research Institute of Surgery, Doping Hospital, Third Military Medical University, Chongqing 400042, China You-Sheng Liu, Research Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China;Expression of β-catenin, cyclin Dl and c-myc in colorectal carcinoma[J];World Chinese Journal of Digestology;2002-03
7 LI BingShun1, WANG Ji2, ZHEN YanJun2, WANG XinGuo2, SUN YanHui2, WANG ShuQin1 and WU ZhongQiu21Department of Infectious Diseases, the Third Hospital2Department of Acupunture, Traditional Chinese Medical College,;Blocking effect of Chinese herbs Yiganxian and PHGF on immuno-damaged hepatic fibrosis in rats[J];;1998-09
8 LI Wen-gui, CHEN Ya-tang(Institute of Infectious and Parasitic Diseases, The First Affiliate d Hospital, Chongqing Medical University, Chongqing 400016, China);Development in the research of Echinococcus granulosus vaccine[J];Chinese Journal of Endemiology;2003-06
9 Zeng Xianxu Guan Jian Han Yanchun et al Department of Pathology,China Medical University,Shen-yang;The Expression and Significance of p-Bad112/136、p-Erk、p-Akt in Progression of Breast Cancer[J];Chinese Journal of Clinical Oncology;2006-13
10 WANG Jianli,CHEN Li,WANG Guilan,CHAO Xiaolei. Department of Dermatology,Affiliated Hospital, Nantong Medical College,Nantong 226001, China;Expression of p63?PCNA and EGFr in Skin Squamous Cell Carcinoma[J];Chinese Journal of Dermatology;2002-02
【Secondary References】
Chinese Journal Full-text Database 5 Hits
1 LI Lei,QU Quan-xin. Department of Gynaecology and Obstetrics,Huanghe Hospital of Tianjin Department of Obstetrisc and Gynecology,the First Central Hospital of Tianjin Medical College,Tianjin 300420,China;Expression of Double-stranded RNA-dependent Protein Kinase in Cervical Lesion Tissues[J];Journal of International Reproductive Health/Family Planning;2009-04
2 LI Lei,QU Quan-xin.Department of Obsterics and Gynecology,Huanghe Hospital,Tianjin 300420,China(LI Lei);Department of Obsterics and Gynecology,the First Central Hospital,Tianjin 300192,China(QU Quan-xin);Relationship Between the Expression of PKR and High Risk HPV in Human Cervical Cancer and Pre-malignant Lesion[J];Journal of International Obstetrics and Gynecology;2009-06
3 WU Wen-feng,WANG Shuang,SUN Zhi-wei Beijing Institute of Biotechnology,Beijing 100071,China;The Advances on Screening Technology of Phage-Display Antibody Libraries[J];Letters in Biotechnology;2007-03
4 XIE Xiao-fang1, SHEN Yong-mei 1* , YANG Xiao-chun1, DONG Ning-zheng2, BAI Xia2, SHI Yi-zhen1 1Department of Clinical Laboratory, Second Affiliated Hospital of Soochow University, Suzhou 215004; 2Jiangsu Institution of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215006, China;Construction and screening of the specific Fab phage antibody library against Raji cell strain[J];Chinese Journal of Cellular and Molecular Immunology;2007-02
5 SHEN Yong-mei1,2,YANG Xiao-chun3,DONG Ning-zheng4,BAI Xia4 1Radioimmunoassay Center, 2Department of Clinical Laboratory,3Department of Magnetic Resonance,Second Affiliated Hospital, Soochow University,Suzhou 215004;4Jiangsu Institutie of Hematology,First Affiliated Hospital,Soochow University,Suzhou 215006,China;Generation,screening and preliminary identification of specific Fab phage antibody library against Daudi cell strain[J];Chinese Journal of Cellular and Molecular Immunology;2009-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved