GABA, cAMP and cGMP changes after fetal cerebellar transplantation in rats with ataxia
Lu Qin-chi; Cai Yan; Zhu Hua, et al. (Neurobiology Laboratory and Department of Neurology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001)
Cerebellar ataxia model was produced by direct stereotactic injection of kainic acid (a neuroexcitotoxin) into the rat cerebellum. After an interval of 2￣3 weeks, the embryonic (14￣16 days of gestation) cerebellar suspension was transplanted into the cerebellar region of the models. The animals were sacrificed after three months. GABA and other amino acid, cAMP and cGMP were measured. The results showed that the fetal cerebellum transplantation could make the decreased cGMP increase and increased GABA decrease.