Tripterygium Wolfordii combined with low-dose Cyclosporin A inhibited porcine intestinal allograft rejection
Liao Cai-xian; Li Jie-shou; Li Ning, et al. (Department of Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515)
This paper presented segmental intestinal allotransplantation in pigs. Four animals received high- dose Cyclosporin A (CsA) for 100 days, then shifted to Tripterygium Wolfordii(TW) in the surviving pigs, 2 died of pneumonia respectively on the 92th and 97th postoperative day. The other 2 survived for more than 281 and 302 days. Five pigs were treated with low-dose CsA and were killed on 12±3th day because their grafts were destructed by acute rejection. In five animals, the combined administration of TW and low-dose CsA was given for 100 days, afterwards TW was the only immunosuppressant used in the surviving animals, none of 5 succumbed to infection: one died of unknown cause on the 135th postoperative day, one died of the native intestinal obstruction on the 166th postoperative day, and the remaining three pigs in this group survived for more than 166, 274,and 274 days respectively. These results indicated that TW had some immunosuppressive effects, and that antirejection treatment with TW and low-dose CsA could be considered as an acceptable therapy in small bowel allotransplantation in pigs.