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Allogeneic bone marrow transplantation in children (Six cases report)

Huang Zhi-guang; Zhou Zhi-fen; He Xing, et al. (Nanfang Hospital, First Military Medical University, Guangzhou 510515)  
From July, 1985 to December, 1991 , six children (4 cases with B-thalassemia and 2 with aplastic anemia) underwent allogeneic bone marrow transplantation in our hospital. Their ages were from 11 months to 10 years. One had HLA-identical sibling donor and others had haplotype or one HLA antigen mismatched donors. Functional graft was documented in 3 cases. One case had disease free for eight years. The factors of successful engraftment, including the degree of HLA compatibility, the intensity of pretreatment regimen and the preventing and treating of GVHD and infections, are discussed.
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