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Effect of Oleanolic acid on immunological reconstitution of allogeneic bone marrow transplantation in mice

Zhang Yong-fa; Xinxiang Medical college, Henan 453003)  
The T-cell- depleted allogeneic bone marrow transplantation (ABMT) successfully reconstituted the immunological function of the lethally irradiated mice. But the recovery was slow. However, in the Oleanolic acid (OLA) administrated group, the PFC and mitogenic responses were significantly increased and with a tendency to improve DTH response. Further investigation revealed that the IL-2 production of ABMT mice was seriously impaired, but after OLA administration, the production was significantly improved. Furthermore, the supernatant of the splenocyte culture of ABMT mice was able to inhibite nonspecificly the mixed lymphocyte reactions. After nemoval of the T cells, the supernatant lost its inhibitory effect. In OLA administrated group, there was a tendency of decreasing the inhibitory effect.
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