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Preliminary observation of the combination of arsenic trioxide and all-trans retinoic acid for the treatment of acute promyelocytic leukemia

ZHAO Yao-zhong, LI Hong-qiang, LI Da-peng, LI Rui, QI Jun-yuan, WAN Chang-chun, ZHOU Chun-lin, WANG Zhi-qiang, QIAN Lin-sheng. Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China  
Objective To observe the efficacy and side effect of the all-trans retinoic acid (ATRA) and arsenic trioxide(As 2O 3) combination in acute promyelocytic leukemia (APL). Methods Twenty APL patients were treated with the ATRA and As 2O 3 combination, and 18 of them could be evaluated. The treatment protocol was as following: 10 mg As 2O 3(0.1% solution)in 500 ml 50 g/L glucose solution for intravenous drip over 4 to 6 hours once a day, ATRA was given 25 mg/m 2 every day. Results Seventeen of the 18 patients achieved complete remission (CR), the CR rate was 94.4%. All 14 newly diagnosed patients and 3 of 4 relapsed patients achieved CR. No significant side effect was observed. Conclusion The As 2O 3 and ATRA in the treatment of APL can obtain a higher CR rate and a shorter duration for achieving CR.
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