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Preliminary study of the effect of HLA-Cw on haploidentical hematopoietic stem cell transplantation

YANG Ming-zhen WU De-pei QIU Hui-ying TANG Xiao-wen MIAO Miao JIN Zheng-ming WU Xiao-jin SUN Ai-ning CHANG Wei-rong HE Jun DI Wen-ying Department of Hematology,the First Affiliated Hospital of Suzhou University,Jiangsu Institute of Hematology,Suzhou 215006,China  
Objective To investigate the effect of HLA-Cw on haploidentical hematopoietie stem cell transplantation(HHSCT)without T-cell depletion.Methods HLA-Cw were detected with PCR-SSP,the clinical data of 21 cases of haploidentical hematopoietic stem cell transplantation,including 8 standard risk and 13 high risk cases from July 2002 to March 2006 were summarized,and the effect of HLA-Cw in HHSCT was analyzed.Results Twenty patients achieved sustained,full-donor-type engraftment.The HLA-Cw matched and mismatched groups attained neutrophil recovery at a median of 12 days and 13 days,and platelet recovery to more than 20×10~9/L at a median of 20 days and 23 days respectively(P0.05).The cumula- tive incidences of grades Ⅱ-Ⅳ acute GVHD were 76.9% in HLA-Cw matched group and 14.3% in the mismatched group(P0.05).The incidences of chronic GVHD were 85.7% in HLA-Cw matched group and 57.1% in the mismatched group(P0.05).The 28 months disease-free survival probabilities were 49.0% in HLA-Cw matched group,and 85.7% in the mismatched group(P0.05).The Karnofsky score of sur- vival patients was over 90%.Conclusion HLA-Cw mismatched in donor and recipient of HHSCT is benefi- cial for reducing Ⅱ-Ⅳ aGVHD,and being in favor of long term survival.
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