Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《CHINESE JOURNAL OF HEMATOLOGY》 1994-01
Add to Favorite Get Latest Update

DETECTION OF AML_1-/ETO FUSION mRNA IN ACUTEMYELOGENOUS LEUKEMIA-M_(2b)

Wang Jianxiang; Hao Yushu;Xiao Zhijian ; et al(Institute of Hemarology, CAMS, Tianjin, 300020)  
bout 90% of patients with acute myelogenousleukemia (AML)-M_(2b) have the unique chromosomeabnormality, t (8; 21) reciprocal translocation. It hasbeen shown recently that t (8 ; 21) results in AML_1-ETOfusion gene. By using reverse transcriptase-polymerasechain reaction (RT/PCR), the transcript of AML_1-ETO fusion gene was assayed in 22 cases of AML_1-M_(2b)including 16 cases with t(8 ; 21), 2 without t(8 ; 21) and4 without karyotypic definition. The AML_1-ETO fusionmRNA was detected in all cases studied. Parallel studyshowed that the transcript of AML_1-ETO fusion genecould not be detected in 5 cases of t (8; 21 ) negativeAML including 2 cases ofM_(2b), 2 cases of M_4[and 1 caseM_3 . Our results indicated that AML_1-ETO fusion genecould be regarded as a molecular marker of AML-M_(2b).
【Fund】: 国家自然科学基金,中国医学科学院青年基金,天津市自然科学基金
【CateGory Index】: R733.71
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved