Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

ENHANCING EFFECT OF TUMOR NECROSIS FACTOR(TNF)ON THE ANTLEUKEMIA ACTIVITY OF LAK CELLS

Lou guoliang;Min Bihe;Meng Peilin;et al(Changhai Hospital,Second Military Medical Universi-ty,Shanghai,200433)  
eripheral blood mononuclear cells(PMBNC)of pa-dents with acute leukemia were induced by interleukin-2(IL-2)and TNF.It was found that TNF(500U/ml)alone was unable to induce LAK activity and could not enhance the LAK activity induced by IL-2 at optimalconcentration(1000U/ml),but it could increase the LAK activity induced by suboptimaldose IL-2(10~100U/ml).The TNF/IL-2‘synergistic effect on LAKactivity was significantly inhibited by anti-TNF McAb(Z_8)or anti-IL-2Rβchain McAb (TU_(27).In addition,the antileukemia activities ofTNFand LAK cell could be markedly augmented when they acted together.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved