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STUDY ON THE EFFECT OF ELlMlNATlON OF RESlDUALLEUKEMlC CELLS lN VlVO BY ALTERNATlVE HEMl-BODY IRRADlATlON

Chu Jianxin;Zhan Junming;Ying Honggnang;et al(Institute of Hematology,CAMS,Tianjin,300020)  
or further enhancing the effect of elimination of mi-nimal residual leukemia by alternative hemi-body irradia-tion(HBI),this study was completed on parent cell lineof BNML model.The results showed that the treatmentof″CTX+alternative HBI″not only could reconstructhemopoiesis without bone marrow transplantation, butalso made the animals survive longer time and some ofthem be cured. Otherwise, the factors of influence ofcurative effects of the different designs of″CTX+alter-native HBI″were investigated.The results showed thatthe curative effects were closely related to the effect ofthe precondition,the time to start irradiation and theinterval between two irradiations.A best design of″CTX+alternative HBI″have been proposed.Thisstudy provides an experimental evidence for using thenew strategy in clinic.
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