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STUDY ON THE BONE MARROW MEGAKARYOCYTE lNADULT CHRONlC PRlMARY THROMBOCYTOPENlCPURPURA

Li Junmun;Shen Zhixiang;Wang Zhenyi;et al(Reijin Hospital,Shanghai Second Medical University,Shanghai,200025)  
n the basis of standardization of megakaryocyte(MK)count in routinely examining bone marrow smears70 thrombeytopenia cases were classified into threegroups:the group with increased number of MK (38),the group with normal number of MK (24) and thegroup with decreased number of MK(8).MK of vari-ous stages was further studied by means of immunomor-phometric method and in vitro megakaryocytopoiesis.The results showed:In the group with increased MK,the number of various stages MK was markedly in-creased,but the number of BFU-MK and CFU-MK wasnormal.Promegakaryoblasts and megakaryoblasts wereslightly decreased and the number of BFUMK was de-various stages MK in the group with decreased MK wassignificantly decreased,so were BFU-MK and CFU-MK. The patients in the group with increased MK re-sponded well to prednison,but the result of the treat-ment was unsatisfied in the groups with normal and de-creased MK.
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