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CLINCAL APPLICATION OF AUTOLOGOUS BONE MARROW TRANSPLANTATION IN THE TREATMENT OF CHILDREN WITH VARIOUS MALIGNACIES

Wang Yaoping,Tang Jingyan,Ying Daming,et al(Shanghai Institute for pediatric research,Shanghai,200092)  
orty four children with various malignancies received autologous bone marrow transplantation(ABMT)from 1980 to Feb.1993 in our hospital.Among them,37 had different types of malignant brain tumors,3 ad- vanced non-Hedgkin' s lymphoma,2 neuroblastoma atIV stage and 2 acute lymphoblastic leukemia in CR_1.The results indicated that①ABMT was one of the mosteffective methods in the treatment of childhood malig-nant brain tumors,but the patient should receive furthermaintenance chemotherapy for 3 years after ABMT.②children with malignant lymphomas, advanced neurob-lastoma and acute leukemias should first receive combi-nation chemotherapy to achieve complete remission be-fore undergoing ABMT. ③if the absolute neutrophilcount delayed to recover after ABMT,GM-CSF shouldbused to promote the recovery and④ABMT was asafe,effective and less expensive method in the treat-ment of children with advanced malignancies.
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