TREATMENT OF ACUTE LEUKEMIA WITH MICROWAVE PURGED AUTOLOGOUS BONE MARROW TRANSPLANTATION:A CLINICAL ANALYSIS OF 35 CASES
Zheng Huajin;Su Yi;Zhao Yuehua;et al(General Hospital of Chengdr Army District,Chengdu,610O83
utologous bone marrow transplantation(ABMT)was carried out in 35 leukemia patients. The autografts were purged in vitro by mi crowave generating hyper-thermia (42℃)for one hour.Out of the 35 patients,19 were AML(CR_1)3nd 16 ALL(CR_1).The median age was 27(10～43)years. All patients engrafted success-fully after ABMT. The median durations of continuouscomplete remission and disease free survival(DFS)were 22(3 ～ 63)and 35 months respectively. Four cases re-lapsed in 3 to 8 months after ABMT. Two patients with ALL developed central nervous system leukemia in 12and 15 months respectivelv after ABMT. The overall 5year DFS and relapse probability were 65.3%and 18. 3%respectively.