AUTOLOGOUS BONE MARROW TRANSPLANTATIONWTTH MARROW GRAFTS PURGED IN VITRO BY HYPERTHERMIA AND LIOUID CULTIVATION FORTREATMENT OF ADULT ACUTELEUKEMIA
Da Wanming;Zhong Jianting;Bai Hai;et al(Department of Hematology ,Lanzhou General Hospital,Lanzhou,730050)
n theprevious study,we havedemonstratedthat thein vitro purging effect of hypert hermia could be signifi-cantly enhanced when combined with liquid marrow cul-tivation. In this report, we used this combined purgingprocedure in autologous bone marrow transplantation(ABMT)for the treatment of 7 adult patients with a-cute leukemia and one with Hodgkin's lymphoma(HL),whose marrow was involved with tumor cells. After ABMT,6 patients got continuous complete remission(CCR)with a mean follow-up of more than 4 months,one died from disease Dfree accidence in more than 4 months post ABMT,and one died from colibacillus sep-ticemia at day 14 post ABMT. It is considered that the clinical results of ABMT with combined pu rging of hy- perthermia and liquid culture in vitro are encouraging,but definite efficacy needs longer follow-up of more pa- tients.