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Effect of specific removal of circulating tumor necrosis factor-α by immunoadsorption on hepatocellular oxidant stress during endotoxin shock

LONG Hai-bo,ZHANG Xun,HOU Fan-fan.Department of Nephrology, Nanfang Hospital, First Military Medical University,Guangzhou 510515,China [  
Objective To evaluate the effect of specific removal of circulating tumor necrosis facfor-α(TNF-α) by immunoadsorption on hepatocellular oxidant stress during endotoxin shock.Methods New Zealand white rabbits were injected intravenously with Lipopolysaccharide(LPS,Escherichia coli O 111 :B4,8 0×10 9 cfu/kg)and undergone hermoperfusion through a column containing immunoadsorbent produced by the attachment of anti-TNF-α monoclonal antibody to agarose beads at 1st hour after LPS injection.The plasma nitrite (NO - 2,one of the stable end products of nitric oxide)and malondialdehyde(MDA)levels,blood superoxide dismutase(SOD)activities,as well as serum alanine transaminase and aspartate transaminase levels were detected,At 24th hour after injecting LPS,the MDA levels and SOD activities of livers were measured also.Results After immunoadsorption treatment, the concentration of plasma NO 2 - was significantly decreased but it was significantly higher than the baseline value,and reduced productions of oxygen free radicals,as well as attenuated injury of liver function were observed.Conclusion Specific removal of circulating TNF-α by immunoadsorption can reduce the production of oxygen free radicals and inhibit hepatocellular oxidant stress. [
【Fund】: 国家自然科学基金!批准号 :3 93 70 3 3 6
【CateGory Index】: R392.32;R364.14
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