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Experimental studies on the conscious status and vital signs influenced by midbrain reticular formation injury

CHANG Peng-fei 1,WANG Zhong-cheng 2,ZHANG yin 2,et al. 1Neurosurgical Department ,First Hospital ,Dalian Medical University,Dalian 116011 2Beijing Neurosurgical Instisute,Beijing 100050,China [  
Objective To investigate the effects of midbrain reticular formation injury on the conscious status and vital signs of cats,and reveal the mechanism of unconsciousness caused by midbrain injury .Methods Three kinds of different severe damage (slight, moderate and severe) in MRF were made by means of stereotaxical electrolytic lesions .Conscious status and vital signs of cats were observed ,investigated in comparison with histopathological findings in order to know the correlation between the changes of conscious status and vital signs ,as well as the possibility of consciousness recovery .Results The electrolytic injury of MRF can cause significant and specific changes of conscious status and vital signs. These changes are in unison and synchronized and closely related to the severity of MRF injury Conclusions Significant and specific changes of vital signs and unconsciousness can be caused by MRF injury, which are positively related to the severity of injury of MRF. These changes are recoverable in most cases even with severe damage in MRF. [
【Fund】: 国家自然科学基金!批准号 3 96 0 0 15 1
【CateGory Index】: R651.15
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