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Clinical study on changes of endothelin,TXB_2 and 6-keto-PGF_(1α) in plasma of patients with coronary heart disease

LIU Wen-ming,ZHANG Yi-na, FU Jin, et al. 1The Second Hospital Chang zhou Jiangsu,213003. 2Department of Greontology,The Second Affiliated Hospital,Harbin Medical Univercity,Harbin 150086,China [  
Objective To study the effect of endothelin(ET),thromboxane B 2(TXB 2)and 6-keto-PGF 1α on coronary heart disease (CHD).Methods Plasma ET,TXB 2 and 6-keto-PGF 1α concentrations were determined simutaneously in 23 patients with Unstable anging (UA),20 patients with acute myocardial infarction (AMI)and 20 healthy subjects by radioimmunoassay (RIA).Results The values of plasma ET,TXB 2 in the onset of UA patients were markedly higher than those post onset and in controls( P 0 01).The values of plasma ET,TXB 2 befor thrombolytic therapy in AMI patients were significantly higher than those after thrombolytic therapy in AMI patieuts and in controls( P 0.01),6-keto-PGF 1α were significantly reduced ( P 0 01 and 0.05),The values of plasma ET,TXB 2 befor thrombolytic therapy in AMI patients were markedly higher than those in the episode of UA patients ( P 0.01),but 6-keto-PGF 1α was no.differences occurred in the two group( P 0.05).Plasma ET,6-keto-PGF 1α concetrations after thrombolytic therapy of AMI group were no differences occurred than those post episode of UA group( P 0.05).Plasma TXB 2 concentrations post episode of UA group and after thrombolytic therapy of AMI group were still higher than the control group ( P 0.01),but 6-keto-PGF1 α was lower than the control group ( P 0.001 and 0.05).ET was no differences occurred ( P 0.05).Plasma ET concentrations of CHD displayed a positive correlation with the values TXB 2/6-keto-PGF 1α (AMI group:r=0.81 P 0.01,UA group:r=0.68, P 0.01).Conclusions Metabolism disorder of ET and TXB 2/6-keto-PGF 1α may lead to spasm of coronary artery.and thrombogenesis of coronary artery.The interaction between ET and TXB 2/6-keto-PGF 1α my be involved in the progress from UA to AMI. [
【Fund】: 黑龙江省教委科研资金
【CateGory Index】: R541.4
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