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《Chinese Journal of Critical Care Medicine》 2003-01
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Changes and clinical significance of the plasma levels of adrenomedullin in the patients with serious brain injury

LI Tan-shi 1,ZHANG Ying-li 1,BAN Yu 1,et al. 1 General Hospital of PLA,Beijing 100853,China  
Objective To investigate the role of adrenomedullin(ADM),endothelin-1(ET-1),norepinephrine(NE)in the pathogenesis of serious brain injury.Methods Plasma levels of ADM,ET-1 and NE in both pre- and post- operation were measured in 12 patients with serious brain injury in.Results Pre-operation plasma levels of ADM,ET-1 and NE were significantly higher in serious brain injury group than in control group〔(65 63±6 55) mmol/L,(221 91±31 42) mmol/L,(2 37±0 16) ng/mL vs.(21 56±4 21) mmol/L,(77 56±4 21) mmol/L,(0 48±0 07) ng/mL respectively ( P 0 01)〕.It also revealed that the plasma levels of ADM,ET-1 and NE of death group were higher than those of survival group〔(104 59±31 33) mmol/L,(271 34±38 72) mmol/L,(2 88±0 53) ng/mL vs.(57 736±27 63) mmol/L,(184 74±31 42) mmol/L,(2 11±0 466) ng/mL respectively( P 0 01)〕.High hemodynamics state was found in the early stage of serious brain injury patients,and it came to normal gradually in 3~5 days.Conclusion The results indicated that ADM?ET-1?NE played an important role in the pathophysiologic process and had an effect on the hemodynamics of the patients with serious brain injury
【Fund】: 全军“十五”医药卫生科研基金项目 (No 0 1MAY98)
【CateGory Index】: R651.15
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