Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Critical Care Medicine》 2005-01
Add to Favorite Get Latest Update

Detection of thrombus precursor protein in severe sepsis and intervention therapy of low molecular weight heparins and low dose of urokinase

ZHANG Hong-song, LI Pei-jie, CHEN Tian-duo, et al. The Second Affiliated Hospital of Lanzhou Medical College , Lanzhou Emergency Center of Gansu Province , Lanzhou 730030 , China  
Objective To evaluate the significance of the concentration change of plasma thrombus precursor protein (T PP) in severe sepsis and intervention therapy of low molecular weight heparins and low dose of urokinase. Methods Enzyme linked immunosorbent assay (ELISA) was used in the detection of plasma T PP in 25 patients with severe sepsis group . PT , APTT , Fib , D-Dimer were detected and statistical comparison was carried out in 10 patients with ordinary infection and 8 healthy normal controls. At the same time , severe sepsis group were randomly divided into two groups,the 13 patients in the treated group were treated with low molecular weight heparins and low dose of urokinase and conventional treatment,and the 12 patients in the control group were treated with conventional treatment alone.The concentration change of T PP of two groups were compared. Results ① The concentration of T PP and positive rate of D-Dimer in severe sepsis were obviously higher than those in the ordinary infection group and normal control group (all P0.05), but levels of PT,APTT,Fib weren't significantly different among three groups. ② The concentration of T PP of the treated group decreased more obviously than that of the control group. Conclusions T PP detection shows hypercoagulable states of severe sepsis and has higher specificity and sensitivity than D-Dimer , PT, APTT , Fib assay .It can be used as a diagnosis parameter for early hypercoagulable states of severe sepsis. Though intervention therapy of low molecular weight heparins and low dose of urokinase can decrease the concentration of T PP , it has no influence on prognosis.
【Fund】: 甘肃省自然科学基金暨中青年科技基金项目 (ZS991-A2 3 -0 74-Y)
【CateGory Index】: R631
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved