Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
Add to Favorite Get Latest Update

The effects of urapidil in the contents of calcitonin gene related peptide and endothelin in the patients with hypertension

Liang min, Zhang Wei, Liang Ning. Department of Anesthesiology,Haikou City People′ s Hospital,Haikou 570208  
Objective The purpose of this paper is to determine the contents of the calcitonin gene relatecd peptide (CGRP) and endothelin (ET) in the plasma of hypertension and the effect of urapidil on the CGRP and ET. Methods RIA methods was used to measure the CGRP and ET of before and after treatment with urapidil. Results The contents of CGRP in the patients with hepertension was markedly lower than that in normal groups ( P 0 01). The content of ET in the patients with hypertension was markedly higher than that in normal patients ( P 0 01), after treatment with urapidil, the content of CGRP in plasma of patients with hypertension was significantly increased (P 0 01) and ET was significantly decreased ( P 0 01). Conclusio ns Both CGRP and ET could be an important causes of the hypertension and urapidil may markdly increasing the level of CGRP in vivo. Urapidil decreased the blood pressure and meanwhile markdly autagonistic effect to the content of ET. [
【CateGory Index】: R972.4
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 LI Shu wei (Department of Emergency,Jiangmen Central Hospital:Guangdong Jiangmen,529070);A Clinical Analysis of the Treatment of 47 Cases With Hypertensive Emergency by Urapidil in Pre-hospital[J];Journal of Gannan Medical College;2004-01
2 Wang Suozhu,Chen Wei, Zhao Binjiang.Department of Surgery ICU, Beijing Shijitan Hospital,Beijing 100038;Comparison study of urapidil and sodium nitroprusside on perioperative management of abdominal surgery in the aged patients with essential hypertension[J];Modern Medicine Journal of China;2009-05
3 Zhang Wenwu, Zhang Bingyong, Zhao Haiying, et al. Shenzhen Baoan Hospital, Shenzhen 518101;Clinical research of treatment of hypertensive emergency by Urapidil[J];CHINESE JOURNAL OF CRITICAL CARE MEDICINE;1999-04
Chinese Journal Full-text Database 1 Hits
1 Tan Dun-Yong;Zhang Ji-Feng, et al Laboratory of Cardiopulmonary Endocrinology, Beijjng Medical University, Beijing;Antagonistic effect of calcitoain gene-related peptide (CGRP) on endothelin(ET)[J];Chinese Journal of Pathophysiology;1993-05
Chinese Journal Full-text Database 10 Hits
1 Li Yukun, Chen Sujuan, Jiang Yanyong et al. (Department of General Surgery, General Hospital of PLA Beijing 100853, China);Changes of Plasma ET-1/CGRP Ratio During Perioperative Period[J];LABELED IMMUNOASSAYS AND CLINICAL MEDICINE;2000-02
2 Fang Ling, Murong Shenxing, Xu Guoying, et al (Department of Neurology, The Affiliated First Hospital, Fujian Medical University, Fuzhou, 350005);Changes of Calcitonin Gene-related Peptide in Reperfused Rat Brain[J];JOURNAL OF FUJIAN MEDICAL UNIVERSITY;1999-03
3 Cheng Guanghua, Dai Yunhai, Chen Wei, et al Department of Nuclear Medicine, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui (241001);Study on the Mechanism of~(153)Sm-EDTMP Palliation for Painful Skeletal Metastases[J];Journal of Radioimmunology;2004-03
4 Jing Daping Neurosurgical Departement, the Second Hospital of Wuhu, Anhui (241000)Cheng GuanghuaDepartment of Nuclear Medicine, Yijishan Hospital, Wannan Medical college, Wuhu , Anhui, (241001);Clinical Significance of Measurement of Plasma ET-1 and CGRP Levels in Patients with Traumatic Brain Injury[J];Journal of Radioimmunology;2007-04
5 Li Jihong\ Liu Jiang\ Zhou Dang (The Maternal and Child Health Hospital of Zhuhai,Zhuhai\ 519000\ China) Luo Xiaoyang (The 473 Hospital of PLA,Lanzhou\ 730000\ China);LEVELS OF ENDOTHELIN 1 AND CALCITONIN GENE RELATED PEPTIDE IN THE PLASMA IN PATIENTS WITH PREGNANCE INDUCED HYPERTENSION[J];JOURNAL OF GANSU SCIENCES;1998-03
6 LIU Ying~1,WANG Di-fen~1,WANG Jun-tao~2(1.Department of Intensive Care Unit,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China; 2.Department of Obstetrics and Gynecology,Guiyang Health Institute of Maternity and Infant,Guiyang 550003,China);A Study on the Protective Effect of Propofol Pretreatment against Cerebral Ischemia-reperfusion Injury[J];Journal of Guiyang Medical College;2006-03
7 WANG Ying~1, ZHOU Li~2 (1. Department of Digestive Internal Medicine, The Firt Affiliated Hospita1 of Xuzhou Medical College, Xuzhou 221006, Jiangsu, China; 2. Department of Digestive Medicine, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China);The Content Changes of ET,CGRP,MAD,and SOD,and their Significance in Early Stage of Acute Pancreatitis[J];Journal of Guiyang Medical College;2006-06
8 Ding Sanqiang, Chen Shilun, Chen Ruhua,et al. Department of Anesthesioloty,The First Affiliated Hospital Shantou University Medical College, Shantou,515041;Effects of urapidil on cardiovascular responses to endotracheal intubation in patients with hypertension[J];Guizhon Medical Journal;2001-02
9 Wang Xin,Wang Ying Department of Digestive Internal Medicine,First Affiliated Hospital of Xuzhou Medical College,Xuzhou(221006),China;Changes of the Vaso-active Substances in the Early Phase of Severe Acute Pancreatitis and Its Significance[J];Journal of Radioimmunology;2013-01
10 QU Yaohua 1) ,LI Shulian 2) ,XU Wei 3) 1)Department of Anatomy, Medical College, Henan University, Kaifeng 475001 2)Department of Pathophysiology, Medical College, Henan University,Kaifeng 475001 3)Department of Physiology, Beijing University, Beijing 100083;Effects of taurine on brain ET and CGRP in spontaneously hypertensive rats[J];Journal of Zhengzhou University(Science Medical);2003-04
Chinese Journal Full-text Database 10 Hits
1 Kang Jian; Zhang Jiali;Gao Bingxin; et al.(Department of Cardiology, Beijing Ji Shut Tan Hospital,Beijing 100035);Study on clinical effects and safety of ebrantil for patients with hypertension[J];BEIJING MEDICAL JOURNAL;1999-04
2 Zhang Minying, Zhou Qinhai, Fu Chengzhang, et al. Department of Pharmacology, Nanjing Medical University, Nanjing 210029;Influence of Urapidil on the Contraction of Isolated Tracheal Smooth Muscle in Rabbits[J];ACTA ACADEMIAE MEDICINAE NANJING;1999-04
4 Wang Jing,Wu Yantao.Dept.of Surgery,the First Affiliated Hospital,West China University of Sciences,Chengdu 610041,China;Clinical analysis of 531 cases of abdominal surgery with hypertension.[J];Chinese Journal of Practical Surgery;2001-05
5 LI Lihuan,FU Jiahong,DI Gaomei.Department of Anesthesiology,Cardiovascular Institute and Fu Wai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037;The hemodynamic effects of nicardipine and urapidil in patients undergoing coronary artery bypass grafting during cardiopulmonary bypass[J];CHINESE JOURNAL OF ANESTHESIOLOGY;1999-09
6 YAO Xueyan ,FAN Weihu, CHEN Junzhu, et al Department of Cardiology, First Affiliated Hospital, Zhejiang University, Medical School, Hangzhou 310003, China;Evaluation of efficacy of atenolol and diltiazem-SR in the treatment of hypertension[J];Chinese Journal of Cardiology;2002-12
7 LIANG Min,HUANC Yun- bo, LIANG Ning (Department of Anesthesiology, Haikou City People's Hospital, Haikou 570208, China);Effect of Urapidil on the contents neuropeptide Y in the patients with congestive heart failure[J];CHINESE JOURNAL OF CRITICAL CARE MEDICINE;2000-04
8 Zhang Wenwu, Zhang Bingyong, Zhao Haiying, et al. Shenzhen Baoan Hospital, Shenzhen 518101;Clinical research of treatment of hypertensive emergency by Urapidil[J];CHINESE JOURNAL OF CRITICAL CARE MEDICINE;1999-04
9 Sheng Yanting,Liu Jin,Zhang Tong, et al . ( Department of Internal medicine,Beijing Tiantan Hospital,the Capital University of Medical Sciences,Beijing 100050);COMPARISON OF THE EFFICACY OF URAPIDIL AND TERAZOSIN IN TREATMENT OF ESSENTIAL HYPERTENSION[J];CHINESE NEW DRUGS JOURNAL;1999-09
10 Wang Xiaoyan,Liu Hongguang,Cheng Shaoyuan,et al Department of Cardiology,People's Hospital of Nanshan (Shenzhen 518052);Efficiency and Safety of Urapidil for Hypertensive Emergency[J];Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease;2006-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 WU Yan-mei.Department of Cardiology,The Third Affiliated Hospital of Jinzhou Medical College,Jinzhou 121001,China;Experimental study on protective effects of Urapidil on heart muscle ischemia and reperfusion injury in rats[J];Journal of Chinese Physician;2006-04
2 GONG You-gui (Section 2 of Department of Internal Medicine,2nd People's Hospital of Jiangjin District,Chongqing 402289,China);Effect of sublingual administration of nifedipine and venous injection of urapidil on hypertension emergency[J];Journal of Hainan Medical University;2012-01
3 XU Jun, WANG Li-jun, ZHANG Qi-gao, PENG Yong-ping GONG Jian-bin, YAN Bao-li, CHEN Rui-hua, JIANG Shi-sen (Department of Cardiology,Nanjing General Hospital of Nanjing Command,Nanjing 210002,Jiangsu,China);Monitoring blood pressure changes continuously in severe hypertension after intravenous urapidil[J];Journal of Medical Postgraduates;2004-08
4 WANG Tao,QIN Jian,WANG Jing,WANG Chang-yuan△,LIAO Qiu-ju(Department of Emergency,Xuanwu Hospital Capital Medical University,Beijing,100053,China);Comparison of Nicardipine and Urapidil in Treatment of Hypertensive Emergencies[J];Progress in Modern Biomedicine;2011-21
5 WANG Tian-bao,LIN Wei-hao,YE Zhi-jun,et al.Department of Surgery,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,Gongdong,China;Perioperative Treatment Strategies for Patients with Gastrointestinal Carcinoma Combining with Hypertension[J];Chinese Journal of General Practice;2010-12
6 TAN Cong-ying1,QIN Xing-fa2(1.Shizhu County Daxie Town Health Care Center,Shizhu,Chongqing 409100,China;2.Department of Gynecology and Obstetrics,First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China);Effective analysis on treatment of 100 cases of preeclampsia by urapidil and nitroglycerin[J];Journal of Modern Medicine & Health;2012-11
7 SONG Shang-ming1, ZHU Xing-lei1, ZHOU Sheng-fen2, TANG Yuan-sheng1 (1. Shandong Provincial Hospital, Ji-nan SHANDONG 250021, China; 2. Yiyuan Coun ty People's Hospital, Yiyuan SHANDONG 256100, China);Urapidil vs nicardipine in treating hypertensive emergency[J];Chinese Journal of New Drugs and Clinical Remedies;2005-10
8 SHI Jing,ZHAO Min,XIE Wei-xing,YU Li-xin,YUAN Hui-ying(Fangqian Branch Hospital Attached to Wuxi First People's Hospital,Wuxi,214111,China);Comparison of clinical efficacy between urapidil and other vasodilators in acute left heart failure[J];Journal of Pharmaceutical Practice;2007-05
9 ZHOU Jing 1 ,JIANG Xue hua 1* , ZHANG Xun 2 ,YANG Jun yi 1 (1 School of Pharmacy,Sichuan University, Chengdu 610041 China;2 Second affiliated Hospital, Sichuan University,Chengdu 610041 China);Relative bioavailability and the correlation study on urapidil sustained-release capsules between in vitro and in vivo[J];Chinese Pharmaceutical Journal;2005-02
10 GUAN De-ming,CHEN Li,HUANG Yong-lin ( Cooperative Group for Observation of Phase Ⅱ Clinical Trial on Urapidil Injection );Efficacy and safety of urapidil injection in treatment of severe essential hypertension[J];Chinese New Drugs Journal;2004-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved