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《CHINESE JOURNAL OF CRITICAL CARE MEDICINE》 1999-01
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The effects of urapidil in the contents of calcitonin gene related peptide and endothelin in the patients with hypertension

Liang min, Zhang Wei, Liang Ning. Department of Anesthesiology,Haikou City People′ s Hospital,Haikou 570208  
Objective The purpose of this paper is to determine the contents of the calcitonin gene relatecd peptide (CGRP) and endothelin (ET) in the plasma of hypertension and the effect of urapidil on the CGRP and ET. Methods RIA methods was used to measure the CGRP and ET of before and after treatment with urapidil. Results The contents of CGRP in the patients with hepertension was markedly lower than that in normal groups ( P 0 01). The content of ET in the patients with hypertension was markedly higher than that in normal patients ( P 0 01), after treatment with urapidil, the content of CGRP in plasma of patients with hypertension was significantly increased (P 0 01) and ET was significantly decreased ( P 0 01). Conclusio ns Both CGRP and ET could be an important causes of the hypertension and urapidil may markdly increasing the level of CGRP in vivo. Urapidil decreased the blood pressure and meanwhile markdly autagonistic effect to the content of ET. [
【CateGory Index】: R972.4
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