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The Changes of Several Kinds of.Cardiovascular-Regulating Hormones After Percutaneous Balloon Mitral Valvuloplasty

Li Dazhu, Cao Linsheng (Institute of Cardiovascular Diseases, Tongji Medical University, Wuhan)  
The plasma levels of atrial natriuretic factor (ANF), angiotension II (AII, vaso-pressin (VP) and endogenous digitalis-like factor (EDLF) were determined in 23 patients with mi-tral stenosis before and after percutaneous balloon mitral valvuloplasty (PBMV). Before PBMV, the plasma levels of ANF and EDLF were elevated in all patients with lower level of All than nor-mal. After the procedure, with a concomitant decrease of left atrial pressure, the plasma ANF de-creased at 15 minutes (from 317. 4±96. 2 to 164. 9±56. 8ng/L , P0. 01), and EDLF fell at 45 minutes (from 423. 5±113. 3 to 279. 3±75. 2ng/L. P0. 05) but All increased signicantly at this time. The plasma All and EDLF concentration returned to normal and the ANF remained higher than normal 24 hours after the dilatation. The plasma VP level only showed a transient increase at 15 minutes after the dilation (from 6. 3±1. 0 to 9. 6±2. 5ng/L , P0. 05), and then to the base-line. The positive correlations were found between left atrial pressure and ANF (r = 0. 63, P 0. 01) ,EDLF(r = 0. 58,P0. 05). The results suggested that in addition to improving the hemody-namic state, PBMV could regulate the secretion of cardiovascular active hormones in disorder in patients with mitral stenosis.
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