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EFFECTS OF TEA POLYPHENOLS ON ACETAMINOPHEN-INDUCED MICRONUCLEI OF RAT BLASTOCYST IN VIVO

Lou Yijia and Zhou Zhangdong(Department of Pharmacy,Zhejiang Medical University)  
Chemical prevention with effects of tea Polyphenols (TP) on ace t aminophen-induced micronuclei of rat blastocyst in the were evaluated by cytological and cytogenetic toxicity analysis.Female rats were treated with acetaminophen (Ace) 0. 5 g/kg ig on day 3 of pregnancy (positivevaginal smear=day 0) or Ace O. 5 g/kg ig on day 3 after treating with TP 0.1, 0. 2,and 0. 4 g/kg ig on day 0, 1, 2 and 3 of pregnancy, respectively. Blastocysts were collected on day 4, andevaluated for cell number and micronucleus. The frequency of micronuclei was 12. 2%, and thefrequency of blastocysts with micr0nuclei was 33. 3%, while in the Ace group exposed to Ace0. 5 g/kg both of them markedly higher than those in control group. But in TP-pretreatedgroups, the frequency of micronuclei was 6. 2‰ 4. 1‰,and 3. 7‰; the frequency of blastocystswith micronuclei was 18. 3‰, 14. 3‰,and 12. 5‰; both of them were reduced in a dose dependent manner. The results demonstrated that TP could chemically protect rat blastocysts fromacetaminop hen-induced micronuclei in vivo.
【Fund】: 国家自然科学基金
【CateGory Index】: R96
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