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A MODEL OF AIRWAY ALLERGIC INFLAMMATION IN THE SD RATS

Zhao Menghui; Zhang Lifen; Zhang Weiping(Laboratory of Neurobiology, Zhejiang Medical University)  
We established a model of antigen-induced airway allergic inflammation in ovalbumin (OA )-sensitized SD rats. Two weeks after sensitization with OA,the animals were exposed to 1% OAaerosol for 15 min. The total count of leukocytes and the percentage of eosinophils in the bronchoalveolar lavage(BAL) significantly increased 6 h and 24 h after exposure. Pathological resultsof the lung sections indicated that there were edema and infiltration of eosinophils around thebronchiole and small vessels. The imaging analyses with computer showed that the area of bronchiole wall area and the number of eosinophils within per unit of wall area enhanced remarkably.We conclude that inhalation of antigen can induce allergic inflammation of airway in SD rats,andthat SD rats can be used in the investigation of allergic asthma.
【Fund】: 国家自然科学基金;;浙江省分析测试基金
【CateGory Index】: R562.25
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