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A STUDY ON DIGOXIN INTOXICATION IN PATIENTS WITH HIGH SERUM DIGOXIN CONCENTRATION

Xie Bo and Jin Peisheng(Department of Cardiology, Huzhou Second Hospital)  
To investigate the diagnostic value of the high serum digoxin concentration (HSDC) to intoxication,the relevant factors and the criteria of intoxication,a retrospective study of 59 patientswith SDC2. 6 nmol/L was performed. We found that 72, 9% of patients with HSDC exhibitedclinical signs or symptoms of digoxin toxicity. The serum digoxin levels of the intoxication groupwere higher than those of the non-intoxication group (P0.05 ) and an obvious overlap wasshown between groups in the region of 2. 7 to 5. 4 nmol/L. Multiple stepwise regressive analysisfurther revealed that the relevant factors of intoxication were heart failure,myocardiac ischemiaor anoxia,acid-base imbalance,SDC and drug interaction(P0. 01 ). In addition, l6 cases experienced the aggravation of heart failure suggestive of digoxin intoxication which resolved afterwithdrawal or reduction bf digoxin. The results indicate that HSDC can reflect the possibility ofintoxication to some extent and the absolute toxic levels are greater than 5. 4 nmol/L, that thecorrection of the clinical risk factors will help to reduce the intoxication occurrence,and that theaggravation of heart failure of digoxin-induced myocardiac toxicity should be added as one of thecriteria for intoxication.
【CateGory Index】: R96
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