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Effect of Epimedium Flavanoids on Neuro-inflammatory Reaction in Alzheimer Disease Model Mice Induced by Lateral Ventricle Injection of β-amyloid

LIN Li-li,SONG Qiu-jie,YE Cui-fei,et al.The Department of Pharmacology,Xuanwu Hospital of Capital Medical University,Key Laboratory for Neurodegenerative Diseases of Ministry of Education,Beijing 100053,China  
Objective To investigate the effect of Epimedium flavanoids(EF)on neuro-inflammatory reaction in Alzheimer disease(AD)mice model.Methodsβ-amyloid 1-40(Aβ1-40)was injected to the right lateral ventricle of 2-month-old male ICR mice to induce AD model.Morris water maze and step-through tests were used to measure the learning and memory ability of mice.The concentrations of interleukin-1β(IL-1β)and tumor necrosis factor α(TNF-α)in the hippocampus were determined by radioimmunoassay.The expression of glial fibrillary acidic protein(GFAP)positive cells(astrocytes)was detected by immunochemistry staining.ResultsCompared with the sham-operation group,the learning and memory ability decreased(P0.05,P0.01),the concentrations of IL-1β and TNF-α in the hippocampus increased(P0.01)and the expression of astrocytes in the hippocampus elevated(P0.05)in Aβ1-40 injection model mice.Intragastric administration of EF(100 and 300 mg/kg)for 3 weeks significantly improved the learning and memory ability(P0.05,P0.01),decreased IL-1β and TNF-α concentrations in the hippocampus(P0.05,P0.01)and inhibited the expression of astrocytes in the hippocampus(P0.05),compared with Aβ1-40 injection model mice.ConclusionEF can decrease the inflammatory reaction in the brain of mice induced by Aβ.
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