PRELIMINARY STUDY ON THE TABLET PROCESSING OF ANTITUMOR POLYSACCHARIDE——POLYACTIN A
Qiu Wan-chou (Sichuan Industrial Institute of Antibiotics, Chengdu 610051) Shu Yun-cheng He Jing and Jiao Yang (Chengdu Army NO. l Pharmaceutical Plant, Chengdu 610083)
The authors reported that several kinds of diluents, binders, lubricants were being formulated in the tablet processing technology of antitumor polysa-ccharide, Polyactin A, and the representative formula was proposed. The effects of the water content of granules and the pressure of the compressed press to the hardness of tablets and their disintegration time were also evaluated. Weight variaton of the tablets and the uniformity of the drug content revealed that the formula proposed, is satisfactory. Utilizing the formulation to scale-up the tablet making resulted that the quality of the tablets met the requirement of the state pharmacopoeia.