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《Chinese Journal of Antibiotics》 2005-01
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Study on cooling crystallization process of avermectins

Xie Zhi 1,2 , Chang Zhi dong 1, Sun Xing hua 1, Hu Xin 1, Wang Ming mei 2 and Li Wen jun 2 (1 Laboratory of Separation Science and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080; 2 Department of Chemistry, Applied Science School, University of Science and Technology Beijing, Beijing 100083)  
Avermectins, which are produced by Streptomyces avermitilis , are a family of macrocyclic lactone compounds. Eight compounds with similar structures in avermectins fermentation both make the purification of avermectins very difficult. The crystallization is the most important technique to purify avermectins and obtain good crystalline quality. In the work, operation parameters such as cooling way, stirring speed and seeding in avermectins crystallization were studied. Results showed that the crystal quality was best when using programmed cooling, stirring at 120r/min and seeding at supersaturation degree of 1 2~1 4.
【Fund】: 创新研究群体 No.2 0 2 2 1 60 3;; 国家自然科学重点基金 No.2 0 2 360 50。
【CateGory Index】: TQ465
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