Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Antibiotics》 2005-01
Add to Favorite Get Latest Update

Study on cooling crystallization process of avermectins

Xie Zhi 1,2 , Chang Zhi dong 1, Sun Xing hua 1, Hu Xin 1, Wang Ming mei 2 and Li Wen jun 2 (1 Laboratory of Separation Science and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080; 2 Department of Chemistry, Applied Science School, University of Science and Technology Beijing, Beijing 100083)  
Avermectins, which are produced by Streptomyces avermitilis , are a family of macrocyclic lactone compounds. Eight compounds with similar structures in avermectins fermentation both make the purification of avermectins very difficult. The crystallization is the most important technique to purify avermectins and obtain good crystalline quality. In the work, operation parameters such as cooling way, stirring speed and seeding in avermectins crystallization were studied. Results showed that the crystal quality was best when using programmed cooling, stirring at 120r/min and seeding at supersaturation degree of 1 2~1 4.
【Fund】: 创新研究群体 No.2 0 2 2 1 60 3;; 国家自然科学重点基金 No.2 0 2 360 50。
【CateGory Index】: TQ465
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 8 Hits
1 Mi Yan,Liu Jingshen(Jilin Agricultural University,Changchun,Jilin 130118,China);The Research Progress of Solution Crystallization Methods[J];Academic Periodical of Farm Products Processing;2011-05
2 WU Song-gu1,LIU Tian-tian1,dong wei-bing2,GONG Jun-bo1,2(1.The State Research Center of Industrialization for Crystallization Technology,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;2.Key Laboratory Modern Drug Delivery and High Efficiency in Tianjin University,Tianjin 300072,China);Purification of Avermectins by Solvent-out Crystallization[J];Agrochemicals;2011-09
3 WANG Miao-miao1,2,LIU Zheng1,2,YUAN Shuai1,2,HAO Zai-bin1,2(1.College of Chemical and Biological Engineering,Guilin University of Technology,Guilin 541004,China;2.State Key Laboratory for Biology of Plant Disease and Insect Pests,Chinese Academy of Agricultural Sciences,Beijing 100193,China);Application of Antibiotics to Plant Protection and Research Progress of Their Isolation and Purification[J];Chemistry & Bioengineering;2011-09
4 HE Huan-jun,QI Li-na,YAO Wei-fang,GONG Ai-jun~*,SONG Xiao-chun(University of Science and Technology Beijing,Beijing 100083,China);Study on the Development of Avermectins[J];Biotechnology;2006-06
5 YAN Ke-yi,GONG Ai-jun,SUN Cui-xia,QIU Li-na(Department of Chemistry,Beijing University of Science and Technology,Beijing 100083,China);Advances in technology for the production of Avermectins[J];Modern Chemical Industry;2006-S1
6 ZHOU Xian-feng,HUANG Yao-jian*,ZHENG Zhong-hui,SHEN Yue-mao(School of Life Sciences,Xiamen University,Xiamen 361005,China);Purify Deacetylmycoepoxydiene with Solventing-out Crystallization[J];Journal of Xiamen University(Natural Science);2010-02
7 Liu Ji~(1,2),Ji Qing-rong~1,Chang Zhi-dong~1,Xie Zhi~1,Zhang Gui-feng~1,Shen Shu-feng~1,Sun Xing-hua~1, Lei Chao~1 and Liu Hui-zhou~1 (Laboratory of Separation Science and Engineering,State Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100080;2 Graduate School of the Chinese Academic of Sciences,Beijing 100080);Study on the crystallization of avermectin crude powder and its impurities analysis[J];Chinese Journal of Antibiotics;2006-01
8 Zhang Chun-tao, Wang Jing-kang and Wang Yong-li (School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072);Advances in ceftriaxone sodium crystallization process[J];Chinese Journal of Antibiotics;2006-07
【Citations】
Chinese Journal Full-text Database 5 Hits
1 LU Jie; WANG Jing-kang(1. Chemical Engineering Departmet, Shanghai University, Shanghai 200072, China)(2. Institute of Chemical Engineering, Tianjin University, Tianjin 300072, China);Effects of Operational Parameters on Crystal Sizes of Procaine Benzylpenicillium[J];JOURNAL OF CHEMICAL ENGINEERING OF CHINESE UNIVERSITIES;1999-06
2 Song Yuan;Studies on Commercialization of Avermectins[J];Fine and Specialty Chemicals;2002-21
3 HAN Jia-bin, WANG Jing-kang(School of Chemical Engineering, Tianjin University, Tianjin 300072, China);Metastable Zone of Caffeine in Water and Ethanol[J];Journal of Tianjin University;2003-06
4 TIAN Yi Min, YANG Hong, LI Yan Fang (Hebei Yiling Pharmaceutical Group,Shijiazhuang 050091);Improvement of Avermectin Crystallization Technology[J];Chinese Journal of Pharmaceuticals;2002-09
5 Wang Hong, Luo Wen-bo, Yu Shu-juan and Gao Da-wei(Food and Biologiacal Engineering College of SCUT, Guangzhou 510640);Research on influential factors and optimizationin the process of cry stallization of tobramycin[J];Chinese Journal of Antibiotics;2002-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 CAI Jian guo,ZHOU Zhan yun (Chemical Engineering Researh Center,ECUST,Shanghai 200237,China);The Effect of Temperature on Morphology of HMX in the Processes of Supercritical Carbon Dioxide Antisolvent Recrystallization[J];Chinese Journal of Explosives & Propellants;2000-04
2 CAI Jian-guo, DENG Xiu (Chemical Engineering Research Centre ECUST, Shanghai200237, China);Factors Affecting Particle Size in Supercritical CO_2 Antisolvent Precipitation HMX[J];Chinese Journal of Explosives & Propellants;2003-04
3 Lu Qingwu;A METHOD FOR THE DIRECT PREPARATION OF OCTOGEN AFFORDING DIFFERENT PARTICLE SIZE DISTRIBUTION[J];Acta Armamentarii;1989-01
4 Li Qunsheng(1)( College of Chemical Engineering, Beijing University of Chemical Technology, Beijing, 100029;)2)( Department of Chemical Eiginceering, Tianjin, University, Tianjin. 300072);A Study on Continuous Multistage Countercurrent Fractional Crystallization Process[J];JOURNAL OF BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY;1997-01
5 Yang Yan Zhong Jie Shen Zhi gang Liu Xiao lin Chen Jian feng(Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029, China);Micronization of cephradine[J];Journal of Beijing University of Chemical Technology;2004-03
6 Cadmium YellowDong Shulian(Department of Applied Chemistry, Beijing Inshtute of Chemical Technology, Beijing, 100029);Preparation of Superfine Heat Resistant[J];;1994-02
7 LONG Bing-wen, WANG Li-sheng(School of Chemical and Enviornment Engineering, Beijing Institute of Technology, Beijing100081, China);Crystallization Thermodynamics of m-Phthalic Acid in Water and Aqueous Acetic Acid Solutions[J];Journal of Beijing Institute of Technology;2005-08
8 TAO Feng-yun~1,ZHANG Xin-miao~2,MA Run-yu~(2)(1.Biochemical Engineering College of Beijing Union University,Beijing 100023,China;(2.College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029,China);Research Progress on Lysozyme Crystallization[J];Journal of Beijing Union University(Natural Sciences);2006-03
9 WANG Jingyu, ZHANG Jinglin, XU Wenzheng (Department of Environment and Safety Engineering,North China Institute of Technology, Taiyuan 030051 Shanxi, China);Ultrafine HMX explosive preparation with atomizing kinetic crystal method[J];Explosion and Shock Waves;2003-03
10 HUANG Kai1,2,Guo Xue-yi1,ZHANG Duo-mo1(1.School of Metallurgical Science and Engineering,Central South University, Changsha 410083,China;2.State Key Laboratory of powder Metallurgy,Central South University,Changsha 410083,China);Fundamental theories of particle size and morphology controlling for ultrafine powders in wet chemical precipitation process[J];Materials Science and Engineering of Powder Metallargy;2005-06
China Proceedings of conference Full-text Database 2 Hits
1 Hang fangxue~(1,2) Qiu taiqiu~1 1.School of Light Industry and Food Engineering,South China University of Technology,Guangzhou 510640,China; 2.School of Light Industry and Food Engineering,Guangxi university,Nanning 530004,Guangxi,China;The application of power ultrasound to andrographolide solventing-out crystallization process[A];[C];2007
2 Li Jun Yuan Junsheng Li Xiulun (Chemical Engineering School,Tianjin University,Tianjin 300072);Effects of Inert-solid Particles on the Circulating Fluidized Crystallization and the Model of Nucleation Rate[A];[C];2000
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LUO Deng-lin,QIU Tai-qiu,LU Qun(Light and Chemical Industry Institute,South China University of Technology,Guangzhou 510640,China);Ultrasound and its applications(Ⅲ)——Uses of ultrasound in separation technologies[J];China Surfactant Detergent & Cosmetics;2006-01
2 LU Jie; WANG Jing-kang(1. Chemical Engineering Departmet, Shanghai University, Shanghai 200072, China)(2. Institute of Chemical Engineering, Tianjin University, Tianjin 300072, China);Effects of Operational Parameters on Crystal Sizes of Procaine Benzylpenicillium[J];JOURNAL OF CHEMICAL ENGINEERING OF CHINESE UNIVERSITIES;1999-06
3 HANG Fang-xue1,2,QIU Tai-qiu1 (1. School of Light Industry and Food,South China University of Technology,Guangzhou 510640,China; 2. School of Light Industry and Food Engineering,Guangxi University,Nanning 530004,China);Effect of Ultrasound on Andrographolide Solventing-Out Crystallization Process[J];Journal of Chemical Engineering of Chinese Universities;2008-04
4 WANG Rong 1,ZHAO Ying_yi 2,LIANG Hong_yu 1 ZHANG Yun_kai 1,WEI Yu_tuo 1,HUANG Ri_bo 1(1.Biotecb Experimental Center,Guangxi University,Nanning Guangxi 530005; 2.Biotechand Sucrose Industrial Engineering College,Guangxi University,Nanning Guangxi 5;The Optimium Culture Conditions of Avermectins[J];Journal of Guangxi Teachers College;2002-02
5 LI Feng-gang1,LI Chang-hai2,JIA Dong-mei2,YAO Hui-min2(1 School of Chemical Engineering,Changchun University of Technology,Jilin Changchun 130012;2 Department of Chemistry and Chemical engineering,Binzhou University,Shandong Binzhou 256603,China);Progress in the Application of Macroporous Ion Exchange Resin[J];Guangzhou Chemical Industry;2010-03
6 WANG Lin-hui(Hebei Weiyuan Pharmaceutical Co.Ltd., Shijiazhuang 050000, China);Effect of the trace element Co~(2+)on production of antibiotic AVM[J];Journal of The Hebei Academy of Sciences;2003-03
7 ZNANG Gang,HE Bin-hong,SHEN Huang-hong(1.Hunan Yueyang City Potassium Salt Science Research Institute,Yueyang Hunan 414000 China;2.Chemistry & Chemical Engineering Department,Hunan Institute of Technology,Yueyang Hunan 414000 China);Progress and Application for Cooling Crystallization Technology of Potassium Nitrate[J];Chemical Fertilizer Design;2008-02
8 Huang Dechun Wang Zhixiang Liu Wei * (College of Pharmacy,China Pharmaceutical University,Jiangsu Nanjing 210009,China; *College of Electrical and Electronic Engineering,Nanjing Normal University,Jiangsu Nanjing 210042,China);The Study on Model Identification of Nucleation and Crystal Growth Stages[J];Chemical Industry Times;2004-03
9 LI Kui lin~1,ZHANG Gang~2 (~1Yueyang Chemical Machinery Plant,Yueyang,414000,Hunan,China;~2Yueyang Research Institute of Silvite,Yueyang,414000,Hunan,China);Design of the Plate Heat Exchanger for Cooling Potassium Nitrate[J];Chemical Engineering & Machinery;2006-01
10 Qin Xuegong (Chemical Engineering Department, Zhejiang University, Hangzhou, 310027);Newly Developed High-pressure Crystallization Separation Technology and Its Research Status[J];Chemical Industry and Engineering Progress;1996-06
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Xu Meiling1,Xu Shulan2,Yi Min2(1.Guang Dong Environment Protection Vocational School,Guangzhou 510665;2.The Biology Control Station of Guangzhou,Guangzhou 510460,China);Residue Dynamics and Safety Assessment of Avermectin in Brassica campestris and Soil[J];Guangdong Chemical Industry;2010-02
2 XU Mei-ling1, WANG Ling1, XU Shu-lan2 (1.Guang Dong Environment Protection Vocational School, Guangzhou 510665,China; 2.Biology Control Station of Guangzhou,Guangzhou 510460,China);Degradation dynamics of avermectin in Brassica chinensis of Guangzhou[J];Guangdong Agricultural Sciences;2010-04
3 SHI Bin,DUAN Mei-rong(School of Chemical Engineering,Tianjin University,Tianjin 300072,China);Purification of((5-Thiazoyl)methyl)-(4-nitrophenyl) Carbonate by Coupling of Reaction and Solvating-out Crystallization[J];Technology & Development of Chemical Industry;2009-07
4 SUN Peng1,2,LIU Jun-guo1,2,YANG Yu-huai3,LIU Lin1,2(1.College of Bioscience and Bioengineering,Hebei University of Science and Technology,Shijiazhuang 050018,China;2.R﹠D Center for Fermentation Engineering of Hebei Province,Shijiazhuang 050018,China;3.Hebei Yuze Chemical Technology Co.,Ltd.,Shijiazhuang 050035,China);Determination and Correlation of Solubilities of Avermectins in Different Systems of Alcohol-Water[J];Journal of Chemical Engineering of Chinese Universities;2010-05
5 Ni Shouliang,Zhang Qunming(Beijing Microstructure Analytical Laboratory,Beijing,100871);HPLC determination of thiotriazinone[J];Analytical Instrumentation;2011-03
6 ZONG Sha-sha1,2,ZHONG Juan1,TAN Hong1,ZHOU Jin-yan1(1.Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu 610041,China; 2.Graduaate University of Chinese Academy of Sciences,Beijing 10049,China);Breeding and high throughput screening overproducing avermectin B1a strains[J];Guangdong Agricultural Sciences;2011-09
7 SHI Bin,ZHANG Guo-liang,ZHANG Feng-bao(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China);Coupling of Reaction and Solvating-out Crystallization to Purify ((5-thiazoyl) methyl)-(4-nitrophenyl) Carbonate[J];Chemical Industry and Engineering;2009-02
8 Li Jing1,Dong Fengshou1,Liu Xingang1,Du Chuanyu2,Zheng Yongquan1(1 Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Key laboratory of pesticide chemistry& Application Technology, Ministry of Agriculture; Beijing 100094;2 Institute for the Control of Agrochemicals of Heilongjiang province, Harbin 150090,China);Determination of Abamectin Residue in Pear by HPLC[J];Pesticide Science and Administration;2008-02
9 ZHANG Qing-lian(Aino Co.,Ltd,North China Pharmaceutical Group,Shijiazhuang 052165,China);Study on COD Removal from Avermectin Waste Water by Yeast Culture[J];Hebei Chemical Industry;2011-08
10 WU Song-gu1,LIU Tian-tian1,dong wei-bing2,GONG Jun-bo1,2(1.The State Research Center of Industrialization for Crystallization Technology,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;2.Key Laboratory Modern Drug Delivery and High Efficiency in Tianjin University,Tianjin 300072,China);Purification of Avermectins by Solvent-out Crystallization[J];Agrochemicals;2011-09
【Secondary Citations】
Chinese Journal Full-text Database 6 Hits
1 Wang Liueheng;Song Chengying;Xu Haishen;Luan Yafei;Yu Lei; Ning Donggang(Dept.of Chem,Eng.,Zhenzhou Inst. of Tech.);Determination of Crystallization Metasatble Zone Width of Dimethyl Fumarate in Methanol Aqueous Solution[J];JOURNAL OF CHEMICAL ENGINEERING OF CHINESE UNIVERSITIES;1995-03
2 HAN Jia-bin1,WANG Jing-kang1,CHEN Jing2 (1.School of Chemical Engineering,Tianjin University,Tianjin 300072,China;2.Hebei Medical University,Shijiazhuang 050017,China);Technical Development on Extraction of Caffeine by Supercritical Fluid Carbon Dioxide[J];Heibei Chemical Engineering and Industry;2002-04
3 Zhao Qian Yu Shujuan Gao Dawei (Res.Inst.of Light Ind.& Chem.Eng.,South China Univ.of Tech.);A NEW NUCLEATION PROCESS FOR FOOD INDUSTRY CRYSTALLIZATION[J];JOURNAL OF SOUTH CHINA UNIVERSITY OF TECHNOLOGY(NATURAL SCIENCE);1996-10
4 Cong Jinyang Liu Shuzhong (Department of Chemical Engineering ,Tsinghua University,Beijing, 100084);Metastable Zone Widths Measurement of Glutamic Acid Crystalization from Industrial Fermentation Broth and Its Significance[J];Food and Fermentation Industries;1995-02
5 Lu Jie and Wang Jingkang (Institute of Chem. Eng., Tianjin University, Tianjin 300072);Study on the solution particle crystallization of procaine penicillin G Ⅰ. Determination of solubilities and supersolubilities[J];CHINESE JOURNAL OF ANTIBIOTICS;1999-05
6 Zhao Qian, Gao Dawei *, Chen Yongquan and Li Bingtao (South China Agriculture University, Guangzhou 510642);Study on the effect of original solvent on erythromycin crystal habit and purity during its solvent out crystallization[J];CHINESE JOURNAL OF ANTIBIOTICS;1999-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved