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《Chinese Journal of Antibiotics》 2005-01
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Study on the reactive crystallization of cefadroxil

Gong Jun bo and Wang Jing kang (School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072)  
Cefadroxil is important as an oral cephalosporin antibiotic. This paper focused on the research of preparation and reactive crystallization processes of cefadroxil. The optimum operation schedule for cefadroxil by indirect crystallization method was obtained, under this condition, the yield, crystal size distribution, crystal habit and purity of cefadroxil product have been extensively improved. The "colloid formed" problems in the direct crystallization process of cefadroxil were also investigated, which gave a good idea for the subsequent studies.
【CateGory Index】: TQ465.1
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