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《Chinese Journal of Antibiotics》 2010-01
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Recent developments of FADH_2-dependent halogenases involved in the biosynthesis of antibiotics

Li Hang1,Zhu Li2 and Chen Dai-jie1(1 Shanghai Institute of Pharmaceutical Industry,Shanghai 200040;2 Shanghai Health Creation Center of Biopharmaceuticals R&D,Shanghai 201203)  
The existence of halogenated nature compounds has been known for over 100 years and nearly 4,500 of them have been identified so far.Many of these compounds are used widely in medicine,such as some important antibiotics.It was largely accepted that most biological halogenation reactions were catalyzed by haloperoxidase until the middle of 1990s.Recent researches on the biosynthesis gene clusters of antibiotics revealed that FADH2-dependent halogenases play a prominent role in enzymatic halogenations.This review will introduce the detection,reaction mechanism,distribution and application of FADH2-dependent halogenases.
【Fund】: 国家自然科学基金资助项目(30772678)
【CateGory Index】: R91
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