Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Antibiotics》 2010-01
Add to Favorite Get Latest Update

Absolute bioavailability of levofloxacin tablet in healthy Chinese male subjects

Cao Guo-ying,Zhang Jing,Yu Ji-cheng,Shi Yao-guo and Zhang Ying-yuan(Institute of Antibiotics,Huashan Hospital,Fudan University,Shanghai 200040)  
Objective To investigate the pharmacokinetics and absolute bioavailability of levofloxacin tablet in healthy Chinese subjects in order to provide rationale for developing safe and effective clinical dosage regimen in Chinese patients.Methods Ten subjects took single oral dose and intravenous of 500mg(100ml) levofloxacin,respectively.The concentrations of levofloxacin in plasma and urine were determined by high performance liquid chromatogram-fluorescence method.Results The pharmacokinetic parameters following single oral dose of 500mg levofloxacin tablet were as follows.The mean of Cmax was(6.20±2.51)mg/L.The mean of Tmax was(0.91±0.54)h.The mean of t1/2 was(6.71±0.88)h.The mean of AUC0-∞ was(41.88±5.72)mg·h/L.The mean of accumulative urinary excretion with 24 hours post dosing was(69.40±7.27)%.The absolute bioavailability was(108.20±12.68)%.Conclusion The results indicate that levofloxacin was absorbed fast and completely.The preparations of tablet and intravenous of levofloxacin were equivalent.
【CateGory Index】: R96
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved