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《Chinese Journal of Antibiotics》 2010-01
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Study on the relationship between class Ⅰ integron and multidrug resistance in Acinetobacter baumannii clinical isolates

Lin Li,Ling Bao-dong,Zhang Xiang and Yuan Bin(Institute of Materia Medica and Department of Pharmacology,North Sichuan Medical College,Nanchong 637007)  
Objective To investigate the distribution and characterization of the classⅠ integron genes(intI1) and integrated gene cassettes in Acinetobacter baumannii isolates and analyze the relationship between class Ⅰ integron and multidrug resistance.Methods Antimicrobial susceptibility testing was determined by serial two-fold dilution.Class Ⅰ integrons were detected by polymerase chain reaction in 112 Acinetobacter baumannii isolates.The integrated gene cassettes were determined by DNA sequencing.Results Most isoliates tested were multidrug resistance.intI1 was detected in 80.4%(90/112) of the isolates.For most antibacterials tested,the resistant rates of integron-positive strains were higher than integron-negative strains.The incidence of multidrug resistant isolates in integron-positive strains(90%) was much higher than those of integron-negative strains(22.7%)(P0.01).The sequencing of integrated gene cassettes showed the class Ⅰ integron habouring the genes of aacA4,aadA1 and catB8,which confer aminoglycoside and chloramphenicol resistance respectively.Conclusions High incidence of class Ⅰ integrons was found in Acinetobacter baumannii isolates and close association existed between class Ⅰ integrons and multiple drug resistance.
【Fund】: 国家自然科学基金(30973662)
【CateGory Index】: R378.2
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