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《Chinese Journal of Antibiotics》 2010-01
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Susceptibility of non-Candida albicans isolates to common antifungal agents

Shen Yin-zhong1 Lu Hong-zhou1,2 and Zhang Yong-xin2(1 Department of Infectious Diseases,Shanghai Public Health Clinical Center affiliated to Fudan University,Shanghai 201508;2 Department of Infectious Diseases,Huashan Hospital Affiliated to Fudan University,Shanghai 200040)  
Objective In order to investigate the prevalence of antifungal resistance of non-Candida albicans isolates.Methods We studied the frequency of resistance profile to amphotericin B,flucytosine,fluconazole and itraconazole of 116 isolates of non-Candida albicans isolates from clinical samples from patients at Shanghai Public Health Clinical Center Affiliated to Fudan University,using Neo-Sensitabs tablet assay.Results All but two C.glabrata isolates were susceptible to amphotericin B.86.4% of C.tropicalis and 80% of C.parapsilosis were susceptible to fluconazole.The resistant rates of C.glabrata isolates to amphotericin B,fluconazole and itraconazole were 3.6%,16.1% and 10.7%,respectively.All C.krusei isolates were resistant to fluconazole and flucytosine.Conclusions We conclude that most non-Candida albicans are susuceptible to amphotericin B,and that C.krusei exhibits low susceptibilities to the triazole agents and flucytosine.This investigation reveals that C.glabrata is less susceptible to the antifungal agents(particularly the triazole agents) than most other species of Candida and exhibits cross-resistance to the triazole agents.
【Fund】: 上海市卫生局青年科研项目(项目编号:2008Y030)“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项(项目编号:2008ZX10001-008)
【CateGory Index】: R519
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1 Deng Jie~(1,2),Zhou Peihong~2,Song Hongtao~1 1.Department of Pharmacy,Fuzhou General Hospital of Nanjing Military District,Fuzhou 350025,China;2.School of pharmacy,Shenyang Pharmaceutical University;Analysis of Use of Antifungal Drugs in Patients in Our Hospital in 2009[J];Chinese Journal of Pharmacoepidemiology;2011-01
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