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《CHINESE JOURNAL OF NATIBIOTICS》 1994-01
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STUDY ON THE PHARMACOKINETICS OF CEFAZOLIN AND HPLC ASSY FOR THE SERUM CONCENTRACTION

Shi Yao-guo;Zhang Qing;Yu Ji-cheng and Zhang Yingyuan(Institute of Antibiotics,Hua Shan Hospital,Shanghai Medical University,Shanghai 200040)  
The results of pharmacokinetics of Cefazolin in healthy volunteers were reported and the HPLC n1ethod for the determination of drug level in body fluids was established,After iv and im injection of lg of Cefazolin,the mean peak serum concentrations were 159.8 ± 17.1mg/Land 74.1 ± 14.2mg/L respectively.The respectiye serum concentrations at8 hours were still 5.6± 3.5mg/L and 10.0± 4.2mg/L.The mean half lifeby the intravenous and intramuscular route were 1.94 ± 0.26 and 2.11 ± 0.59hours respectively,Cefazolin was well absorbed after im injection,theabsolute bioavailability being 92.0± 5.6%,After im injection and iv drip,the mean peak urine concentrations were 4190 ± 2294mg/L and 2320 ± 1700mg/L,the culnulative urinary excretion rates being 86.3 ± 4.2%and 87.5±9.6%respectively HPLC assay for the concentration of Cefazolin inserum is accurate,reproducible,specific and simple,so it can be usedfor the therapeutic drug monitoring of Cefazolin in the patients with sep-cial conditions of pliysiology and pathology.
【CateGory Index】: R914.1
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