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《CHINESE JOURNAL OF NATIBIOTICS》 1994-01
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STUDY ON CLINICAL PHARMACOLOGY OF METRONIDAZOLE IN PREGNNT AND BREAST-FEEDING WOMEN

Shi Yao-guo;Zhang Qing;Yu Ji-cheng and Zhang-ying-yuan(Institute of Antibiotics,Hua Shan Hospital,Shanghai Medical University,Shanghai 200040)Xu Zheng;Qian Yu-yin;Xia Yian-ping and LiQiao-yun(Obstetrics and Gynecology Hospital,Shanghai Medical Unive  
The tissue penetration of Metronidazole in pregnant wom-en of different gestation period and the excretion of the drug in breast milk in breast-feeding mothers were determined.The results showed that Metronidazole penetrated through blood-placenta barrier to various tissues and body fluids easily.Following a single intravenous infusion of 500mg of Metronidazole in pregnant and breast-feeding women,the mean drug concentrations in various tissues and body fluids such as chorion,endom-etrium,fetus,placenta,umbilical tissue and amniotic fluid were 29~53%f that in maternal blood at the same time,umbilical blood being 89%. The drug concentration in breast milk was almost equal to that in mate-rnal blood time. 1 hour after the drug admin istration,the mean milk dr-ug concentration was7.85 mg/L,.67mg/L 12 hours later,The elimina-ion half-life in breast milk was 6.17 ±2.19 h,Based upon the results of this study,the rational use of Metronidazole in pregnant and breast-fee-ding women was proposed.Tbe HPLC assay of the concentrations of Me-tronidazole in tissues and body fluids is simple、sensitive and reliable.It can be used not only in the study of clinical pharmacology but also in monitoring the clinical drug concentration of Metronidazole.
【CateGory Index】: R914.1
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【References】
Chinese Journal Full-text Database 3 Hits
1 LAN Shun,YE Dong-Mei,FAN Lu-Lin(People's Hospital of GuangXi Zhuang Automatic Region,Guangxi Nanning 530021,China);Determination of ornidazole concentration in breast milk by RP-HPLC[J];中国医院药学杂志;2004-02
2 DAI Yinmei, ZHANG Hong, WANG Xiuhua. Department of Obstertics and Gyanecology, The First Affiliated Hospital of Lanzhou Medical College ,Lanzhou 730000,China;Pharmacokinetics of Metronidazole and Tinidazole in Human Dreast and the Effects on Dreast-fed Infants[J];中华围产医学杂志;2002-01
3 LU Hao _ jie, ZHANG Hong, RUAN Zong _ qin, OU Qing _ yu(Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China);Study on the Pharmacokinetics of Metronidazole in Human Milk by Capillary Electrophoresis[J];分析测试学报;2000-04
【Co-references】
Chinese Journal Full-text Database 5 Hits
1 LI Qin1WANG Ben-Jie2GUO Rui-Chen21(Dept. of Pharmacology,Liaocheng People Hospital,Liaocheng, 252000)2(Institute of ClinicalPharmacology, Qilu Hospital,Shandong University, Jinan,250012);Study of the Pharmacokinetics and Bioequivalance of Ornidazole Capsules andImported Ornidazole Tablets in Healthy Volunteers[J];中国临床药理学杂志;2002-02
2 DAI Yinmei, ZHANG Hong, WANG Xiuhua. Department of Obstertics and Gyanecology, The First Affiliated Hospital of Lanzhou Medical College ,Lanzhou 730000,China;Pharmacokinetics of Metronidazole and Tinidazole in Human Dreast and the Effects on Dreast-fed Infants[J];中华围产医学杂志;2002-01
3 TANG Hui-fang~1,GONG Pei-li~1,ZHOU Ji-an~1,LI Ying-qian~1,ZHENG Q i-chang~2, DAI Li-ren~2,MIN Jie~2,LI Xing-rui~3, PENG Zhi-xiang~3,CHEN Ru~3, DING Jun-qing~4, LUO Xin~4,WANG Pei-liang~5,PU Zi-jing~5,YANG Heng~5 (1.Institute of Clinical Pharmacology,;The multi-center clinical study of the efficacy of ornidazole against acute anaerobic infections and vaginalis trichomoniasis[J];中国新药杂志;2001-11
4 Zhang Yingyuan, Zhang Qing, Xu Zhen, et al. Institute of Antibiotics of Huashan Hospital, Shanghai Medical University, Shanghai 200040;Tissue and Body Fluid Distribution of Antibacterial Agents in Pregnant and Lactating Women[J];中华妇产科杂志;1997-05
5 Shi Yao-guo;Zhang Qing;Yu Ji-cheng and Zhang-ying-yuan(Institute of Antibiotics,Hua Shan Hospital,Shanghai Medical University,Shanghai 200040)Xu Zheng;Qian Yu-yin;Xia Yian-ping and LiQiao-yun(Obstetrics and Gynecology Hospital,Shanghai Medical Unive;STUDY ON CLINICAL PHARMACOLOGY OF METRONIDAZOLE IN PREGNNT AND BREAST-FEEDING WOMEN[J];中国抗生素杂志;1994-01
【Secondary References】
Chinese Journal Full-text Database 8 Hits
1 Liu Wei-lin,zhang Lin-jing(Guangxi Institute for Food an Drug Control.Nanning 530021);The Application of Capillary Electrophoresis in Pharmacokinetics[J];中国民族民间医药;2012-03
2 LIN Hongning1,TANG Tiexin2,YANG Jun1,LIU Yan2(1.The First People's Hospital of Zhaoqing,Zhaoqing 526020,China;2.Zhaoqing Medical College,Zhaoqing 526020,China);Optimize the Determination of Metronidazole in Human Milk with Uniform Design Method[J];中国现代应用药学;2011-08
3 WU Mei-xiang~1 LI Huan-de~(2*) (1.Chenzhou Institute for Drug Control,Chenzhou 423000,China;2.The Second Xiangya Hospital of Central South University,Changsha 410011,China);HPLC simultaneous determination of the four nitroimidazoles formulation[J];药物分析杂志;2008-01
4 WANG Xuan-bin,LIU Ying,LIU Ming,DAI Yuan-ying,ZHOU Xiao-yan,HUANG Kai-yun,TANG Bing,GENG Ji-qing(Department of Pharmacy,Renmin Hospital,Yunyang Medical College,Shiyan,Hubei 442000,China);Content determination of Metronidazole in Metronidazole Beclometasone Cream by High Performance Capillary Electrophoresis[J];郧阳医学院学报;2007-06
5 LAN Shun,YE Dong-Mei,FAN Lu-Lin(People's Hospital of GuangXi Zhuang Automatic Region,Guangxi Nanning 530021,China);Determination of ornidazole concentration in breast milk by RP-HPLC[J];中国医院药学杂志;2004-02
6 TIAN Wei Rong, SUN Hua Jun (Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China);Adverse reactions of tinidazole: a literature review[J];药学服务与研究;2002-S1
7 WU Mei-xiang OUYANG Ji-de Chenzhou Institute for Drug Control,Chenzhou 423000 Hunan China;The formulation of metronidazole suppositories by HPLC[J];国际医药卫生导报;2008-20
8 Wu Mei-xiang,OU YANG Ji-de,Tan Zhi-yan.Chenzhou institute for drug control in Hunan province,Chenzhou 423000,China;HPLC simultaneous determination of the four nitroimidazoles formulation[J];国际医药卫生导报;2009-17
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