Process Improvement of m , p-Trifluoromethylbenzonitrile
LIU Gang (Xinjiang Technology Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumgi 830011; Graduate School of the Chinese Academy of Sciences, Beijing 100039,China )
m,p Trifluoromethylbenzonitrile are useful intermediates for synthesis of pharmaceuticals and agricultural chemicals .The article discloses that m, p chlorobenzotrifluoride are converted to m, p trifluoromethylbenzonitrile using Ni(P(C 6 H 5 ) 3 ) 3 as catalyst which give 87.0% and 82.7% conversion respectively. The catalyst is prepared in situ from anhydrous NiCl 2 with PФ 3 in the presence of a reducing powder in a single reactor vessel. The reaction occurs under simple, mild conditions and easily to be controlled and has been carried out in a commercial scale.
【CateGory Index】： TQ246.7