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Effect of prostacyclin on hemorrheology of random skin flaps

Li Dongwei,Luo Jinhui,Liu Jinhan,Yin JunThe 210th Hospital of PAL,Dalian 115021  
bjective:To explore the effect of prostacyclin on hemorrheology and survival of random skin flaps. Methods:A 9 cm×3 cm sized flap was designed on the back of 96 SD rats. Prostacyclin was injected through caudal vein preoperatively (group 1) and postoperatively (group 2), and saline was injected as a controls (group 3).Results:The survival area of flaps in group 2 was greater than that control group.Conclusions:Prostacyclin can improve the viability of flaps by means of lowing platelet aggregation,blood viscosity and plasma fibrinogen.It should be injected immediately after operation.
【CateGory Index】: R622.1
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