The study of medication intervention for anxiety and depression in the diabetes patients with coronary artery disease after percutaneous coronary intervention
YANG Ning;CHEN Shao-bo;WANG Yu-ping;ZHAO Cui;JIANG Tie-min;Department of Cardiology, Armed Police Logistics College;
Objective To explore the effects of medication intervention on the diabetes patients with coronary artery disease after percutaneous coronary intervention(PCI). Methods After psychological assessment, 269 patients with anxiety and depression were randomly into treatment group(151 cases) and control group(118 cases). The treatment group was treated with conventional medication and sertraline hydrochloride for at least 8 weeks, the control group was treated with conventional medication. On the30 thday after PCI, the psychological assessment scores, troponin, CK-MB, fasting blood glucose, uric acid and hs-CRP levels were compared for two groups. Also the incidences of major adverse cardiovascular events(target vascular remodeling, nonfatal myocardial infarction, stroke and cardiovascular death) of two groups were assessed for 180 days. Results On the 30 thday after PCI, SAS and SDS standard scores of treatment group were 36.55 ±3.47 and 40.75±4.23 which were significantly lower than those(43.45 ±4.31 and 47.97±6.16) of control group(P0.05), hs-CRP level [(5.3±0.7) mg/L] of treatment group was significantly lower than that [(9.2±1.3) mg/L] of control group(P0.05). On the 180 thday after PCI, the incidence of major adverse cardiovascular events(1.99%) of treatment group was significantly lower than that(6.78%) of control group(P0.05). Conclusion Anxiety and depression often occur in patients of coronary artery disease with diabetes after PCI. Psychological medication intervention can effectively correct the negative emotion and improve the prognosis of patients.