IMMUNOMODULATION OF GANODERMA LUCIDUM(LYESS.EX FR.)KAKST ON ANTIBODY PRODUCTION OF MOUSE BLYMPHOCYTE AND ACTIVITY OF INTER FERON-γ OF FERON-γ OF MOUSET LYMPHOCYTE
Li Weiyi;Cheng Liping;Chen Guangjie et al. (Department of Immunology Shanghai SecndMedical Uniuersity, Shanghai 200025)
mmunomodulation effect of Ganoderma lucidum(Lyess.ex Fr.)Karst of antibody pro-duction of mouse B lymphocyte and the activity of interferon-γ of mouse T lymphocyte werestudied.Extract of Ganoderma lucidum(Lyess.ex Fr.)Karst was infused into the stomach ofBalb/C mice for 9 days,and infusion with d.w as control.The spleen cell PFC test and agglu-tination titer of anti一SRBCW antibody in serum were measured for both groups 4 days after im-munization by SRBC,Meanwhile,the spleen cell added PHA was incubated for 72 hours,theactivity of interferon-γ in the suppenatant was measured.It was proved that were singnificantincreasein PFC(P0.05)and agglutination titer of anti-SRBC antibody(P0.05)as well asthe activity of interferon-γ (P0. 05)forinterferon-γfor experimental group. Thus,Gano-derma lucidum(Lyess.ex Fr.)Karst might be regard as an immune enhancer.