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Anti-aging effect of hemp seed oil,protein and lignanamide of bama on old mice

CAI Pei1,2,FU Xun1,DENG An-gang1,ZHAN Xue-jing1,CAI Guang-ming1,LI Shun-xiang2(1.Institute of Chinses Materia Medica 302 Hospital of the PLA,Beijing 100039;2.Hunan University of Tradition Chinese Medcine,Changsha 410208)  
Objective To determine the anti-aging effect of hemp seed oil,protein and lignanamide.Methods We used the natural aged mice,fed them with difference doses of hemp seed oil(2.5,5,and 10 mL·kg-1·d-1),protein(1.3,2.6 g·kg-1·d-1)and lignanamides(0.11,0.22 g·kg-1·d-1) every day for 30 d,and detected the total cholesterol(TC),triglyeride(TG),malonaldehyde(MDA) content and superoxide dismutase(SOD) activity in the blood serum of the old mice;the MDA content,SOD,glutathione peroxidase(GSH-Px) activity in the brain and liver tissue,the total antioxidant capcuity(T-AOC) in the brain tissue,the ATP enzyme viability of the liver as well as the Hyp content in the skin.We used a small piece of skin to prepare for the pathological section stained with sirius red.Results Hemp seed oil,protein and lignanamide could obviously improve SOD and GSH-Px viability in the old mice,enhance its anti-oxidation ability,decrease the MDA content,regulate the blood fat,ameliorate its energy metabolism,and also increase the content of Hyp in the skin.The pathological section stained with sirius red also showed significant increase of collagen protein.Conclusion Hemp seed oil,protein and lignanamide have anti-aging effect.Lignanamide of hemp seed is worth further research and development.
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