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《Journal of Chongqing Medical University》 2013-02
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Effects of epimedium total flavonoids on sex hormone in rats with polycystic ovary syndrome

XU Caisheng,LUO Lili,ZENG Ruhui,CHEN Xiaohong(Department of Obstetrics and Gynecology,the First Affiliated Hospital,Shantou Medical University)  
Objective:To explore the effects of epimedium total flavonoids on sex hormone in rats with polycystic ovary syndrome(PCOS).Methods:Letrozole(1 mg/kg)was intragastrically administered in SD rats for 21 d to establish PCOS model.The PCOS rats were randomly divided into 5 groups(n=10):PCOS model group,Diane-35 group(240 mg/kg),epimedium flavonoids group(50,100, 200 mg/kg).In addition,normal control group(n=10)was established.After continuous oral administration for 21 d,rat body weight and ovarian weight were measured and ovarian index was calculated.Serum testosterone(T),follicle stimulating hormone(FSH),estradiol(E2),and luteinizing hormone(LH)were detected with radioimmunoassay.Results:Ovarian weight and ovarian indexes were significantly increased in PCOS group compared with those in normal control group(P0.05).Moreover,PCOS group had higher serum T, LH(P0.001),LH/FSH(P0.01)and lower E2 level(P0.01).After administration for 21 d,ovarian weight,ovarian index(P0.05), serum T,LH(P0.01)and LH/FSH(P0.01)were decreased in 200 mg/kg epimedium flavonoids group compared with those in PCOS model group,but E2 level was significantly increased(P0.01).However,100 mg/kg and 50 mg/kg epimedium flavonoids had weak effects.Conclusions:Epimedium flavonoids can improve hyperandrogenism in PCOS rats,regulate LH/FSH,elevate E2 and improve ovarian function.
【CateGory Index】: R711.75
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