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《Chinese Journal of Practical Pediatrics》 2007-01
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The study of the relationship between leptin and early parenteral nutrition as well as growth of premature infants

ZHOU Ying,LI Ming-xia,PA Ti-man.Department of Neonate,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China  
Objective To investigate the relationship between serum leptin and early nutrition as well as growth of premature infants.Methods Eighty-six cases of premature appropriate for gestational infants were divided into the group of the parenteral nutrition and control group to measure by radioimmunoassay(RIA)their leptin concertrations in the umbilical cord blood and serum on the 7 th day after birth.At the same time,daily nutrition state and physical growth indexes were examined.The correlation among leptin concentrations in cord blood,serum blood on 7 th day after birth and daily intake of the quantity of energy,protein,variance of weight,MAC and the variance of skin-fold thickness were studied.Results(1)The levels of umbilical cord blood leptin were(4.6±3.7)ng/mL and(4.8±2.2)ng/mL in the group of the parenteral nutrition and control group respectively.The levels of serum leptin on 7 th day after birth were(4.3±2.2)ng/mL and(3.1±1.7)ng/mL in the above two groups.The level of serum leptin on 7 th day was significantly lower than that of umbilical cord blood in infants of control group(P0.05).(2)The level of umbilical cord blood leptin correlated positively with gestational age and birth weight(r=0.56,r=0.67).(3)Daily intake of the quantity of energy,protein,leptin and the variance of skin-fold thickness on 7 th day after birth were significantly different between the two groups(P0.05).Conclusion Sufficient supply of energy and protein should be ensured in premature infants.It is important to feed premature infants as early as possible.Premature infants should receive parenteral nutrition as supplements to enteral feeding.Leptin is worthy of recommendation as the laboratory evidence.
【CateGory Index】: R722.6
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