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《Chinese Journal of Practical Pediatrics》 2008-01
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Analysis of endothelin-B receptor gene in Chinese patients with sporadic congenital megacolon

NIU Yang-feng,WANG Guo-bin,LU Xiao-ming,et al.Department of Gastro-intestinal Surgery Center,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China.  
Objective To probe the characteristics of mutations and polymorphisms of EDNRB gene in Chinese patients with sporadic Hirschsprung's(sHD) disease,and analyze the differences between different ethnics with sHD.Methods Blood from 92 cases with sHD,parents of 32 cases(32/92) and 60 normal children as control was collected.Genomic DNA was extracted from peripheral blood and single strand conformation polymorphisms analysis of polymerase chain reaction products(PCR-SSCP) was used to analyze exon-2 of EDNRB gene in all cases.DNA sequencing was used to detect the change of nucleotide in positive cases and compare the characteristics of mutations and polymorphisms with other ethnics.Results No mutations and polymorphic sites were detected in exon-2 of EDNRB gene in all cases with sHD.Conclusion Patients with sHD in Chinese mainland share the same characteristics of no mutations and polymorphisms in exon-2 of EDNRB gene with many ethnics in earth,which is different from that in South Africa and HongKong.
【Fund】: 国家自然科学基金资助项目(30371397);; 湖北省自然科学基金资助项目(2003ABA151)
【CateGory Index】: R726.5
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 Ming-Fa Wei, Guo Wang, Min Zhu, Bin Yi, Xiao-Lin Wang, Jie Han, Hui-Fen Shi, Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China;Mutation of RET oncogene and endothelin B receptor gene in Hirschprung's disease[J];World Chinese Journal of Digestology;2004-03
2 ZHOU Miao-ni,LI Ji-cheng,DING Shi-ping. Institute of Cell Biology, Zhejiang University, Hangzhou 310031, China;Analysis of endothelin-B receptor gene in Chinese patients with sporadic Hirschsprung’s disease[J];Chinese Journal of Pediatric Surgery;2005-07
3 DUAN Xiang-long 1 , ZHANG Xian-sheng 2 , LI Guo-wei 1 (1. Department of General Surgery2. Department of Pediatric Surgery, The Second Hospital, Xian Jiaotong University, Xian 710004, China);Analysis of EDNRB gene in Hirschsprung′s disease[J];Chinese Journal of General Surgery;2004-04
【Co-citations】
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1 NIU Yan-feng,WANG Guo-bin,LU Xiao-ming,et al;Analysis of endothelin B receptor gene in Chinese patients with sporadic congental megacolon[J];Shandong Medical Journal;2006-12
2 WANG Ting1, LIU Mei-ying1, LIU Ya-ping1, YUAN Hong-hua1, GAO Xiu-xian1, ZHU Xiao-rong2, GAO Dian-shuai1 (1 Department of Neurobiology,Xuzhou Medical College, Xuzhou 221004, China; 2 Experimental Animal Center of Xuzhou Medical College, Xuzhou 221004, China);Expression of RET in Mice Substantia Nigra during Dopaminergic Neuron Cells Damage[J];Progress in Modern Biomedicine;2010-15
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4 ZHOU Miao Ni LI Ji Cheng DING Shi Ping (Institute of Cell Biology, Zhejiang University, Hangzhou 310031);CODING-SEQUENCE MUTATION AND POLYMORPHISM ANALYSIS OF EDNRB GENE IN PATIENTS WITH HIRSCHSPRUNG'S DISEASE FROM ZHEJIANG REGION[J];Journal of Molecular Cell Biology;2006-01
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7 Wan-Li Zhang,Guo-Bin Wang,Kai-Xiong Tao,Department of General Surgery,Wuhan Union Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China;Advances in research of the relationship between endothelin receptor type B and Hirschsprung's disease[J];World Chinese Journal of Digestology;2009-25
8 GUAN Tao;LI Ji-cheng;LI Ming-ju et al. Institute of Cell Biology,Zhejiang University,Hangzhou 310031, China;Mutations of RET proto-oncogene in Chinese familial Hirschsprung's disease[J];Chinese Journal of Pediatric Surgery;2003-06
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【Co-references】
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1 ZHOU Miao Ni LI Ji Cheng DING Shi Ping (Institute of Cell Biology, Zhejiang University, Hangzhou 310031);CODING-SEQUENCE MUTATION AND POLYMORPHISM ANALYSIS OF EDNRB GENE IN PATIENTS WITH HIRSCHSPRUNG'S DISEASE FROM ZHEJIANG REGION[J];Journal of Molecular Cell Biology;2006-01
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3 Rong-Lin Zhai Guo-Bin Wang Kai-Lin Cai Department of General Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhart 430022,Hubei Province,China;Application of methylated oligonucleotides:A new strategy for gene inactivation[J];World Chinese Journal of Digestology;2007-31
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【Secondary Citations】
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1 Ming-Fa Wei, Guo Wang, Min Zhu, Bin Yi, Xiao-Lin Wang, Jie Han, Hui-Fen Shi, Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China;Mutation of RET oncogene and endothelin B receptor gene in Hirschprung's disease[J];World Chinese Journal of Digestology;2004-03
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4 XU Juan, WEI Mingfa, SHI Huifen, et al. Department of Pediatric Surgery, Tongji Hospital, Tongji Medical University, Wuhan 430030;Mutation of RET Oncogene in Hirschsprung's Disease[J];CHINESE JOURNAL OF PEDIATRIC SURGERY;1999-01
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