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《Chinese Journal of Practical Pediatrics》 2008-01
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Analysis of distribution and drug resistance of pathogenic bacteria about children's diarrhea in Chongqing area from 1997 to 2006

ZHAO Lan-lan,ZHU Chao-min,ZHANG Ai-hua.Department of infective and digestive division,Children's Hospital Affiliated to Chongqing University of Medical Sciences,Chongqing 400014,China  
Objective To investigate the distribution、epidemic trend and transition of drugs' sensitivity about the pathogenic bacteria of children's bacterial diarrhea the last ten years in Chongqing area,so as to provide important evidence for paediatrics clinical therapy and prevention of bacterial diarrhea.Methods The medical records of 1044 bacterial diarrhea cases which were hospitalized in Children's Hospital affiliated to Chongqing University of Medical Sciences for diarrhea and confirmed as bacterial diarrhea through dejecta culture from 1997 to 2006,were reviewed and the clinical features were analyzed.Results (1)1044 pathogenic bacteria were determined among 11895 medical cases of children's diarrhea in the near ten years,the detection rate was 8.8%.And five genera bacteria were detected,such as Shigella(826)、Salmonella(90)、E.coli(101)、 P.aeruginosa(21) and Proteus(6),appearing decreased year by year.(2) Shigella dominated every year,especially S.flexneri Ⅱ(62.3%),and S.sonnei's constituent ratio raising following the year.All the pathogenic bacteria were most detected from August to November the whole year(58.7%).(3) The detection rate of pathogenic bacteria presented highest in pre-school age(34.4%),lowest in adolescent age(1.4%),and more infectible to Shigella.But turned to E.coli when infancy (36.4%).(4) Ampicillin、rifampicin、furoxone、erythromycin all showed great drug resistant rate,more than 95%,even 100%(ampicillin).The trisubstituted cephalosporin、FQNS and AGS possessed a resistant range of 3.7% to 50.0%、21.6%~87.9%、28.6%~92.5% respectively,and ceftriaxone was most sensitive.Conclusion (1) The pathogenic bacterial detection rate of children's diarrhea decreased year by year in Chongqing area,and dominated as Shigella,but threw over to E.coli when infancy.(2) The trisubstituted cephalosporin was most sensitive among the antibiotics,then FQNS,AGS and the others were drug resistant.
【CateGory Index】: R725.1;R446.5
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