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《Chinese Journal of Practical Pediatrics》 2008-02
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The clinical significance of ANCA in Kawasaki disease

LI Shu-hua,YU Ming-hua,ZHANG Li,et al.Department of Cardiology,Guangzhou Children's Hospital,Guangzhou 510120.  
Objective To probe into the clinical significance of anti-neutrophil cytoplasmic antibody (ANCA) in children with Kawasaki disease (KD).Methods Serum ANCA was measured in 98 children with a diagnosis of Kawasaki disease from November 1,2005 to November 1,2006.We evaluated the relationship between results and IVIG responsiveness,and coronary abnormalities in Kawasaki disease.Results The positive ANCA in KD was about 69.4%.Statistical analysis showed that the positive ANCA was not related to the responding of IVIG (P0.05),but was related to the development of coronary abnormalities( P0.05).Conclusion ANCA perhaps plays an important role in the development of KD in children.ANCA contributes to the development of coronary abnormalities.
【CateGory Index】: R725.4
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