Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Practical Pediatrics》 2012-01
Add to Favorite Get Latest Update

Effects of dust mite allergen-specific immunotherapy on prevention and cure in children with asthma and allergic rhinitis and the reasons of symptom exacerbation during specific immunotherapy

TAN Yong-qiang,BAO Yi-xiao,SHEN Jin,YE Gui-yun,CHEN Liu.Department of Pediatrics,Chongming Branch Hospital of Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 202150,China  
Objective To evaluate the effects of dust mite allergen-specific immunotherapy combined with standardized management on prevention and cure in children with asthma and allergic rhinitis and analyze the reasons of the asthma and allergic rhinitis symptom exacerbation during specific immunotherapy.Methods One hundred and two children with established diagnosis of allergic asthma and allergic rhinitis to dust mite were enrolled in this study from january 2006 to december 2010,of whom 78 children received the treatment with specific immunotherapy(SIT)combined with standardized management for 2 to 4 year(as the test group)and the other 24 served as the control group with inhaled corticosteroids according to Global Initiative for Asthma(GINA)and Allergic Rhinitis and its Impact on Asthma(ARIA)in the same time.At the beginning,6 months,1 year,2 years of the treament and 1 year after the treament,the clinical symptom and acute episode,pulmonery function(Peak Expiratory Flow,PEF)and Chinese children asthma control test(Ch-CACT)of the asthmatic children,symptem scores and Visual Analogue Scale(VAS)of allergic rhinitis were analyzed,while respiratory tract infection of all the patients were recorded at the second year and after 1 year of the treatment.The reasons of the asthma and allergic rhinitis symptom exacerbation during dust mite allergen-specific immunotherapy were analyzed.The data were analyzed by SPSS15.0.Results Compared with control group,the frequency of acute episode,the frequency of respiratory tract infection in test group were significantly decreased at the 2 years of the treament and 1 year after the treament.The PEFof asthmasic children were obviously improved in the test group at the 2 years of the treament and 1 year after the treament and the Ch-CACT were more higher in the test group than the control group at 1 year after the treament.Compared with control group,the symptem scores and VAS of allergic rhinitis were significantly increased in test group at the 6 months,1 year,2 years of the treament and 1 year after the treament.The common reasons of the asthma and allergic rhinitis symptom exacerbation during specific immunotherapy were climatic factor,respiratory tract infection,nasosinusitis and improper room cleared,etc.Conclusion The dust mite allergen-specific immunotherapy can enhance the PEF and Ch-CACT of the asthmasic children,can obviously improve the symptem scores and VAS of allergic rhinitis and it is a persistent and effective means on prevention and cure in children with allergic rhinitis and asthma.The climatic factor,respiratory tract infection,nasosinusitis are common reasons of the asthma and allergic rhinitis symptom exacerbation during specific immunotherapy.
【Fund】: 上海市科委生物医学重点基金(项目编号08411953200);; 上海市卫生局基金(项目编号2009237)
【CateGory Index】: R725.6
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 3 Hits
1 ZHAO De-yu(Department of Respiratory,the Affiliated Nanjing Children′s Hospital of Nanjing Medical University,Nanjing 210008,China);Clinical Manifestation,Diagnosis and Treatment in Children with Difficult Asthma[J];Journal of Applied Clinical Pediatrics;2008-04
2 ZHAO Jing(Asthma Prevention and Education Center,Capital Institute of Pediatrics,Beijing 100020,China);Antigen-Specific Immunotherapy[J];Journal of Applied Clinical Pediatrics;2008-09
3 LIN Yuan-ye1,LIN Guang-yu2,XIE Shu-xia2,CHEN Gui-luan3(1.Department of Pediatrics,Shantou Institute of Medical Sciences,Shantou 515031,Guangdong Province,China;2.Department of Pediatrics,the Second Affiliated Hospital of Shantou University Medical College,Shantou 515041,Guangdong Province,China;3.Department of Pediatrics,the People's Hospital of Chenghai,Shantou 515800,Guangdong Province,China);Low-Dose Erythromycin Treatment on Intractable Allergic Rhinitis Associated with Bronchus Asthma[J];Journal of Applied Clinical Pediatrics;2010-13
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui LUO Yong;Efficacy and Nursing of Salbutamol and Budesonide on Children with Bronchial Asthma Via Ultrasonic Nebulizer Inhalation[J];Journal of Anhui Health Vocational & Technical College;2010-02
2 Pan Daoxiang,Wang Yating,Chen Jiaxin The Department of Pediatric,the First Affiliated Hospital of Anhui Medical University,Hefei 230022;Analysis relative factors of asthma in children and effect with different therapy[J];Anhui Medical Journal;2004-06
3 Luo Houjiang,Pan Jiahua,Ni Chen,et al Department of Pediatrics,The Affilicated Provincial Hospital of Anhui Medical University,Hefei 230001,China;Clinical analysis of the efficacy of 32 cases of the asthma children with tuberculosis infection[J];Anhui Medical Journal;2010-05
4 LI Chuan-jing ,HUANG Qi-ling,XU Hong (Dept of Pediatrics,Suzhou People's Hospital, Suzhou234000);The curative effect of salmeterol and fluticasone propinate inhalation on children asthma[J];Anhui Medical and Pharmaceutical Journal;2005-06
5 CHEN Yun-long,PAN Jia-hua,NI Chen,et al (Dept of Pediatrics,The Affiliated Provincial Hospital of Anhui Medical University,Hefei 230001,China);Clinical effectiveness of oral montelukast combined with inhaled symbicort in the treatment of children with asthma[J];Anhui Medical and Pharmaceutical Journal;2009-12
6 DU Hong-wu(Anhui Mingguang Hospital of Traditional Chinese Medicine,Anhui Mingguang 239400,China);Clinical Study on Treatment of Asthma during Remission Stage in Children with Xianba Decoction[J];Journal of Anhui Traditional Chinese Medical College;2010-03
7 LIU DONG-XIA,LIN RONG-JUN (Department of Pediatrics,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China);INFLUENCING FACTORS OF BRONCHIAL ASTHMA CONTROL IN CHILDREN[J];Acta Academiae Medicinae Qingdao Universitatis;2011-01
8 Chen Zan People Hospital of Lanxi City, Zhejiang Province(321100);Discussion on the Relationship between Pneumonias Mycoplasma Infection and Children Bronchial Asthma[J];Journal of Zhejiang University of Traditional Chinese Medicine;2009-01
9 YANG Yi-qiong,MA Li-wei,YANG Zhan(Department of pediatrics,Chongqing West suburban Hospital,Chongqing 400050,China);Current status investigation analisys of the treatment and management of children bronchial asthma[J];Chongqing Medicine;2010-24
10 Lin Juqing,Huang Chunxiang,Meng Ruanhe Department of Pediatrics,Heji Hospital of Changzhi Medical College;Study on Temperament Characteristic of Children with Asthma[J];Journal of Changzhi Medical College;2009-03
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHANG Wenjing,WU Yuying Department of Otorhinolaryngology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Expression of T-bet and GATA-3 mRNA of lymphatic cells in rat with allergic rhinitis and asthma[J];Journal of Zhengzhou University(Medical Sciences);2008-06
2 YU Yan-yan,LIU Ji-xian,ZHU Hong (Department of Respiratory,the Children′s Hospital Affiliated to Soochow University,Suzhou 215003,Jiangsu Province,China);Effect of Azithromycin on Airway Inflammation in Children with Refractory Bronchiolitis[J];Journal of Applied Clinical Pediatrics;2010-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved