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《Chinese Journal of Practical Pediatrics》 2012-01
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Relationship between antral mast cell and electrogastrography in pediatric functional dyspepsia

QIN Zhao-yuan,Su Ji-ji,HE Zhen,YE Hui-xia.Department of Pediatrics,the First Affiliated Hospital of Sun Yat-sen Universtity,Guangzhou 510080,China  
Objective To investigate the association of mast cells(MC)desity and their activation states with electrogastrography(EGG)in pediatric functional dyspepsia(FD).Methods From Jan.2007 to Jan.2010,40 consecutive patients from pediatric clinic in the First Affliatied Hospital of Sun Yat-sen University diagosed with FD according to Rome Ⅲ criteria were recruited in our study.After an antral biopsy was obtained for calculating the amount and degranulation index of MC,the EGG was recorded for all patients.Results(1)With a mean of(65.7 ± 23.9)%,MC degranulation index was 50% in 82.5% patients.(2)MC density increased in patients with abnormal EGG(P 0.05),compared with the normal EGG.(3)The percentage of preprandial normal slow waves was decreased in patients with increasing mean MC density(P = 0.005)and in patients with increasing peak MC density(P = 0.01).(4)MC degranulation index wasn't correlated with EGG;(5)Increasing mean MC density and increasing peak MC was associated with a decreased percentage of preprandial normal slow waves(P 0.05).Conclusion There is a negative correlation between EGG abnormalities and elevated MC density in pediatric patients with FD.MC may mediate the generation and development of FD through influencing EGG.
【CateGory Index】: R725.7
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