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Changes of Tamm-Horsfall protein and β_2microglobulin level in children with primary nephrotic syndrome.

Liang Dacai,Li Chengrong,Li Yongbei,et al.The Affiliated Children's Hospital of Chongqing Medical UniversityChongqing,400014.  
Objective:To study the significance of TammHorsfall protein (THP) and β2microglobulin (β2MG) changes in children with primary nephrotic syndrome(PNS).Methods:The levels of blood THP and β2MG,quantities of THP and β2MG excreted in urine were determined in 60 cases of PNS during remission and active phase.Results:The blood levels of THP and β2MG were all normal,while the quantity of THP excreted in urine increased persistantly.The excretion was especially obvious in patients who were dependent or resistant to prednisone treatment.The quantity of β2MG excreted in urine was normal in PNS group Ⅰand increased during active phase and returned to normal during remission in PNS group Ⅱ;and increased persistantly in PNS group Ⅲ.β2MG excretion increased in urine may be due to damage to the function of proximal convoluted tubules.Conclusion:THP and β2 MG detection is of great value to PNS.
【CateGory Index】: R726.9
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