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Reactive Essence between Chinese Materia Medica Formula and Human Body:Multiple Genetic Chromatodynamokinetics with ‘Co-network Compatibility and Rainbow Potential’

HE Fu-yuan1,2,3,5,DENG Kai-wen4,LIU Weng-long1,2 SHI Ji-lian1,2,ZOU Huan1,2,TANG Yu2,LIU Ping-an2,ZHOU Hong-hao5(1.Department of Pharmaceutics,Hunan University of Chinese Medicine,Changsha 410208,China;2.Property and Pharmacodaynamic Key Laboratory of Chinese MateriaMedica,State Administration of Chinese Medicine,Changsha 410208,China;3.Pharmaceutical Preparation Technology and Evaluation Laboratory of Chinese Materia Medica,Hunan University of Chinese Medicine,Changsha 410208,China;4.The First Affiliated Hospital,Hunan University of Chinese Medicine,Changsha 410007,China5.Pharmacogenetic Research Institute of Clinical Pharmacology,Central South University,Changsha 410078,China)  
Objective: To deal with the reactive essence between the Chinese materia medica(CMM) formula and human body: multiple genetic chromatodynamokinetics(pharmacodynamics with chromatographic fingerprint),with‘Co-network compatibility and rainbow potential’according to properties and characteristics of disciplines.Method:The research characteristics of pharmacogenetics and pharmacy of CMM formula was analyzed,according to the effective mechanism of constitutes in CMM formula,combined with the requirements of modernization of CMM,to illuminate the modernization thoughts and methods of CMM.Result:The CMM formula,compared with west medicine,is an integer with multiple-constitutes carrying with original biologic genetic polymorphic information,synthesized out under primary and secondary metabolic enzymes,especially cytochrome P-450(CYP450) enzymes,imported into human body and metabolized by CYP450 enzymes,on metabolic actions with ‘co-network compatibility and rainbow potential’regularity,to show effects at end with receptors,similar to metabolic enzymes in primary channels of human being,with‘counter-treatment and complementation’reactions of multiple genetic chromatodynamokinetic by mass law.Conclusion:Conclusion:The pharmacodynamics essence between CMM formula and human body is multiple genetic chromatodynamokinetics among biology,abided by nature biology as common regularity,studied with biologic polymorphic methods.
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