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Effect of Cistanches Herba on the Swimming Ability and Oxidation Resistance of Mitochondrial in Rats

ZHOU Hai-tao1,CAO Jian-min2,LIN Qiang1(1.Beijing Union University,Beijing 100023,China;2.Beijing Sport Universty,Beijing 100084,China)  
Objective:To study the effectd of Cistanche Herba on swimming ablity antioxidant resistance of.mitochondrial in rats Method:One hundred and twenty male Wistar rats were randomly divided into static ig water group(C group),still ig Cistancht Herba group(M group),exercise ig water group(T group),group exercise ig Cistanches Herba 1-4(TM 1-4 group).A professional device ig 1 times a day.TM 1-4 ig dose group were 6.01,9.97,13.94,17.90 g·kg-1,ig volume 5 mL·kg-1,C,T two groups ig distilled water.4 weeks after exhaustive swimming training,measured body weight,swimming time and heart mitochondria in malondialchehy-che(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) levels and other indicators related with fatigue.Result:TM weight of each group is greater than the T group(P0.05),swimming time longer than T group(P0.01),TM each group no significant differences.Result of exhaustive swimming in the MDA content in rat heart mitochondria was significantly increased,T-group and TM 1-4 group were increased to(5.96±0.71),(5.05±0.36),(5.05±0.92),(5.06±0.16),(5.05 ±0.25) μmol·L-1,and that the TM groups were significantly different lower than the T group(P0.01);SOD,GSH-Px activity was significantly decreased(T-group and T1-T4 group,SOD decreased to(209.78±17.21),(249.85±10.93),(253.98±9.64),(259.31±14.57),(259.46±15.73) U·mL-1,GSH-Px decreased to(57.95±11.95),(68.58±6.01),(70.63±5.83),(70.78±7.04),(72.56±4.34) U·mg-1,and that the TM groups were significantly higher than the T group(P0.01);TM of each group showed no significant difference.Conclusion:Cistanches Herba has improved exercise capacity in rat heart mitochondria and the role of antioxidant enzymes,there by reducing free radicals on myocardial sarcoplasmic reticulum and mitochondrial membrane damage,inhibition of high-intensity exhaustive exercise cause myocardial mitochondrial oxidative damage,delay fatigue occurred;have a significant effect at a dose of 6.01 g·kg-1.
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